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Titolo:
THE NEUROBIOLOGY OF LATE-LIFE PSYCHOSIS
Autore:
BROWN FW;
Indirizzi:
EMORY UNIV,WESLEY WOODS GERIATR TEACHING & RES HOSP,EMORY CLIN,SCH MED,1821 CLIFTON RD NE ATLANTA GA 30329
Titolo Testata:
Critical reviews in neurobiology
fascicolo: 3-4, volume: 7, anno: 1993,
pagine: 275 - 289
SICI:
0892-0915(1993)7:3-4<275:TNOLP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; COCAINE-INDUCED PARANOIA; LATE-ONSET SCHIZOPHRENIA; CENTRAL NERVOUS-SYSTEM; HUMAN-BRAIN; FUNCTIONAL PSYCHOSES; ALZHEIMERS-DISEASE; VISUAL HALLUCINATIONS; HUNTINGTONS CHOREICS; MAGNETIC-RESONANCE;
Keywords:
PSYCHOSIS; GERIATRICS; SCHIZOPHRENIA; DELUSIONS; HALLUCINATIONS; LATE-LIFE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
108
Recensione:
Indirizzi per estratti:
Citazione:
F.W. Brown, "THE NEUROBIOLOGY OF LATE-LIFE PSYCHOSIS", Critical reviews in neurobiology, 7(3-4), 1993, pp. 275-289

Abstract

Developments in understanding the neurobiology of late-life psychosishave centered primarily on structural, functional, and neurochemical factors. Structural factors have included the study of white matter hyperintensity signals on magnetic resonance imaging of the brain, and associated vascular diseases as possible etiologies of psychosis in theelderly. Functional studies have continued to note frontal and medialtemporal lobe dysfunction. Important neurochemical factors in psychosis include dopamine systems, serine metabolism, and the role of neurotensin. The neurochemical basis of psychosis has been proposed as a dysfunction of the corticostriatal pathways with negative feedback disinhibition of the thalamus with resultant sensory flooding, which leads to the perception of psychosis in susceptible patients.

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Documento generato il 17/01/20 alle ore 20:12:13