Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PEPTIDASES IN THE CNS - FORMATION OF BIOLOGICALLY-ACTIVE, RECEPTOR-SPECIFIC PEPTIDE-FRAGMENTS
Autore:
DAVIS TP; KONINGS PNM;
Indirizzi:
UNIV ARIZONA,COLL MED,DEPT PHARMACOL TUCSON AZ 85724
Titolo Testata:
Critical reviews in neurobiology
fascicolo: 3-4, volume: 7, anno: 1993,
pagine: 163 - 174
SICI:
0892-0915(1993)7:3-4<163:PITC-F>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN SYNAPTIC-MEMBRANES; BETA-ENDORPHIN; RAT-BRAIN; NEUROTENSIN METABOLISM; SMALL-INTESTINE; CHOLECYSTOKININ; LOCALIZATION; HYDROLYSIS; PITUITARY; SLICES;
Keywords:
PEPTIDASE; PEPTIDE METABOLISM; NEUROTENSIN; OPIOID RECEPTOR; PEPTIDE FRAGMENTS; PEPTIDE-E; NEUTRAL ENDOPEPTIDASE; AMINOPEPTIDASE; METALLOENDOPEPTIDASE; ECTOENZYMES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
T.P. Davis e P.N.M. Konings, "PEPTIDASES IN THE CNS - FORMATION OF BIOLOGICALLY-ACTIVE, RECEPTOR-SPECIFIC PEPTIDE-FRAGMENTS", Critical reviews in neurobiology, 7(3-4), 1993, pp. 163-174

Abstract

Peptides function as chemical signals between cells of multicellular organisms, or different organisms, via specific receptors on target cells. Many hormones, neuromodulators, and growth factors are peptides. Because there is no known reuptake system for peptides at the nerve terminal, the biological activity of peptides in the extracellular spaceis regulated by enzymatic degradation and extracellular metabolism. For example, angiotensin I is processed extracellularly in the lung by angiotensin-converting enzyme (ACE; E.C.3.4.15.1), a peptidyl dipeptidase, to form the potent vasoconstrictor hormone angiotensin II. When neuropeptides are released from neurons into the extracellular space, specific peptidases also can modulate the peptidergic signal by generating smaller, biologially active fragments via products with similar ordissimilar characteristics of the parent peptide. Therefore, receptor-binding selectivity of a released peptide hormone can be regulated bypeptidases. Because peptidases may play a key role in the extracellular regulation of peptidergic signaling, alterations in peptidase activities by drugs or disease states may lead to disruptions in biologicalhomeostasis. The subject of this article is the role of peptidases inthe central nervous system in the formation of biologically active, receptor-specific peptides from peptide E, beta-endorphin, neurotensin,and cholecystokinin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:13:11