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Titolo:
EFFECTS OF SR 141716A AFTER ACUTE OR CHRONIC CANNABINOID ADMINISTRATION IN DOGS
Autore:
LICHTMAN AH; WILEY JL; LAVECCHIA KL; NEVIASER ST; ARTHUR DB; WILSON DM; MARTIN BR;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,MCV CAMPUS,POB 980613 RICHMOND VA 23298
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 357, anno: 1998,
pagine: 139 - 148
SICI:
0014-2999(1998)357:2-3<139:EOS1AA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ANTINOCICEPTION; RECEPTOR ANTAGONIST; RHESUS-MONKEYS; PHARMACOLOGICAL ACTIVITY; SELECTIVE ANTAGONIST; BRAIN CONSTITUENT; IN-VIVO; ANANDAMIDE; RATS; AGONIST;
Keywords:
CANNABINOID; ANANDAMIDE; DELTA(9)-TETRAHYDROCANNABINOL; SR 141716A; WITHDRAWAL PRECIPITATED; DEPENDENCE; STATIC ATAXIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
A.H. Lichtman et al., "EFFECTS OF SR 141716A AFTER ACUTE OR CHRONIC CANNABINOID ADMINISTRATION IN DOGS", European journal of pharmacology, 357(2-3), 1998, pp. 139-148

Abstract

The effects of dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl(SR 141716A), a specific cannabinoid receptor antagonist, were assessed in the dog static ataxia test after either acute treatment with twocannabinoid receptor agonists, Delta(9)-tetrahydrocannabinol and arachidonylethanolamide (anandamide), or chronic treatment with Delta(9)-tetrahydrocannabinol. As previously reported, acute intravenous (i.v.) injected Delta(9)-tetrahydrocannabinol produced dose-dependent cannabinoid effects, including marked static ataxia, prancing, loss of muscletone, and incoordination. The behavioral profile of anandamide was distinctly different in that it produced a loss of muscle tone and considerable sedation with little static ataxia, prancing, or incoordination. Despite these qualitative differences between the two agonists, SR 141716A blocked the acute behavioral effects of both drugs indicating a cannabinoid receptor mechanism of action. Interestingly, SR 141716A was able to precipitate a withdrawal syndrome in Delta(9)-tetrahydrocannabinol-tolerant dogs, but failed to produce any observable effects in dogs receiving chronic vehicle injections. Acute toxicity caused by anandamide, which was not blocked by SR 141716A, precluded conducting dependence studies with this drug. The Delta(9)-tetrahydrocannabinol precipitated withdrawal syndrome included diarrhea, vomiting, excessivesalivation, decreases in social behavior, and increases in restless behavior and trembling. This is the first demonstration of a precipitated withdrawal syndrome in a non-rodent species. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:10:48