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Titolo:
NICOTINE ADMINISTRATION IMPAIRS SENSORY GATING IN LONG-EVANS RATS
Autore:
FARADAY MM; RAHMAN MA; SCHEUFELE PM; GRUNBERG NE;
Indirizzi:
UNIFORMED SERV UNIV HLTH SCI,DEPT MED & CLIN PSYCHOL,4301 JONES BRIDGE RD BETHESDA MD 20814
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 61, anno: 1998,
pagine: 281 - 289
SICI:
0091-3057(1998)61:3<281:NAISGI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; FEMALE RATS; PREPULSE INHIBITION; FOOD-CONSUMPTION; BODY-WEIGHT; GENETIC INFLUENCES; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; D-AMPHETAMINE; RESPONSES;
Keywords:
NICOTINE; ACOUSTIC STARTLE REFLEX; PREPULSE INHIBITION LONG-EVANS RATS; STRAIN DIFFERENCES; HOUSING CONDITIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Faraday et al., "NICOTINE ADMINISTRATION IMPAIRS SENSORY GATING IN LONG-EVANS RATS", Pharmacology, biochemistry and behavior, 61(3), 1998, pp. 281-289

Abstract

In rats, effects of nicotine administration on sensory gating as indexed by prepulse inhibition (PPI)of the acoustic startle reflex (ASR) are unclear. We have found that nicotine administration enhances ASR and PPI in Sprague-Dawley rats, but other investigators, using Long-Evans rats, have reported no effects or enhancement of PPI only. Numerous methodological differences exist among studies in addition to subject strain, however, making it unclear whether inconsistent behavioral responses are the result of different experimental procedures or indicatea true strain difference. To investigate the role of strain in nicotine's effects on ASR and PPI, 192 male and female Long-Evans rats were administered 12 mg/kg/day nicotine via osmotic minipump for 14 days using identical methodologies employed in studies with Sprague-Dawley subjects. Effects of grouped vs. individual housing on these responses also were examined. Nicotine administration impaired ASR and PPI in Long-Evans subjects. These effects occurred in female rats regardless of housing condition, and interacted with housing in male rats. Results indicate that sex and housing are important variables in nicotine's effects. Results suggest that subject strain may be an important variablein nicotine's effects on sensory gating, and that responses of Sprague-Dawley vs. Long-Evans rats may represent a true strain difference. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:18:36