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Titolo:
TREATMENT OF POLYCYSTIC OVARIAN DISEASE DURING ADOLESCENCE WITH ETHINYLESTRADIOL CYPROTERONE-ACETATE VERSUS A D-TR-6-LHRH ANALOG
Autore:
CREATSAS G; HASSAN E; DELIGEOROGLOU E; TOLIS G; ARAVANTINOS D;
Indirizzi:
UNIV ATHENS,ALEXANDRA HOSP,DEPT OBSTET & GYNECOL 1,DIV PEDIAT ADOLESCENT GYNECOL,9 KANARI STR GR-10671 ATHENS GREECE
Titolo Testata:
International journal of gynaecology and obstetrics
fascicolo: 2, volume: 42, anno: 1993,
pagine: 147 - 153
SICI:
0020-7292(1993)42:2<147:TOPODD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; SECRETION; WOMEN;
Keywords:
POLYCYSTIC OVARIAN DISEASE; ADOLESCENCE; LHRH ANALOG; CYPROTERONE ACETATE; HIRSUTISM; OLIGOMENORRHEA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
G. Creatsas et al., "TREATMENT OF POLYCYSTIC OVARIAN DISEASE DURING ADOLESCENCE WITH ETHINYLESTRADIOL CYPROTERONE-ACETATE VERSUS A D-TR-6-LHRH ANALOG", International journal of gynaecology and obstetrics, 42(2), 1993, pp. 147-153

Abstract

OBJECTIVE: This study was undertaken to compare the clinical and endocrinological results of two kinds of treatment on adolescents with polycystic ovarian disease (PCOD). METHOD: Forty-five adolescents with PCOD were randomly allocated into two groups, treated either with ethinylestradiol (EE)/cyproterone acetate (group A) or the GnRH analog D-Tr-6-LHRH (group B). RESULT: No significant changes were detected on the body mass index and waist-hip circumference. A significant improvementof hirsutism was noticed in both groups of patients. A normal menstrual period was recorded in group A adolescents while all group B patients became amenorrheic. A favorable decrease of ovarian volume was detected in both groups. LH/FSH ratio and DELTA4-androstenedione serum levels were found significantly reduced in both groups in comparison to pre-treatment levels. The comparison between the two groups, after 6 months, showed significantly lower values of LH/FSH ratio in group B cases. CONCLUSION: Both forms of treatment are safe and effective to a various degree for the management of PCOD adolescents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:27:36