Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENETIC INFLUENCES OF CHROMOSOMES 5Q31-Q33 AND 11Q13 ON SPECIFIC IGE RESPONSIVENESS TO COMMON INHALED ALLERGENS AMONG AFRICAN-AMERICAN FAMILIES
Autore:
HIZAWA N; FREIDHOFF LR; EHRLICH E; CHIU YF; DUFFY DL; SCHOU C; DUNSTON GM; BEATY TH; MARSH DG; BARNES KC; HUANG SK;
Indirizzi:
JOHNS HOPKINS ASTHMA & ALLERGY CTR,DIV CLIN IMMUNOL,5501 HOPKINS BAYVIEW CIRCLE BALTIMORE MD 21224 JOHNS HOPKINS ASTHMA & ALLERGY CTR,DIV CLIN IMMUNOL BALTIMORE MD 21224 JOHNS HOPKINS SCH HYG,DEPT BIOSTAT BALTIMORE MD 00000 JOHNS HOPKINS SCH HYG,DEPT EPIDEMIOL BALTIMORE MD 00000 QUEENSLAND INST MED RES BRISBANE QLD 4006 AUSTRALIA ALK LABS HORSHOLM DENMARK HOWARD UNIV,COLL MED,DEPT MICROBIOL WASHINGTON DC 00000 NHLBI BETHESDA MD 20892
Titolo Testata:
Journal of allergy and clinical immunology
fascicolo: 3, volume: 102, anno: 1998,
pagine: 449 - 453
SICI:
0091-6749(1998)102:3<449:GIOC5A>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE ANALYSIS; SERUM IGE; UNDERLYING ASTHMA; ATOPY; LOCALIZATION; SENSITIVITY; RESPONSES; MARKERS; DENSITY;
Keywords:
ATOPY; SKIN PRICK TEST; CHROMOSOME 5Q31-Q33; CHROMOSOME 11Q13; MULTIPOINT LINKAGE ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
N. Hizawa et al., "GENETIC INFLUENCES OF CHROMOSOMES 5Q31-Q33 AND 11Q13 ON SPECIFIC IGE RESPONSIVENESS TO COMMON INHALED ALLERGENS AMONG AFRICAN-AMERICAN FAMILIES", Journal of allergy and clinical immunology, 102(3), 1998, pp. 449-453

Abstract

Background: We have recently conducted a genome-wide screening for genes influencing Dermatophagoides pteronyssinus-specific IgE responsiveness as a part of the Collaborative Study on the Genetics of Asthma (CSGA), which showed evidence for linkage in some regions, including chromosomes 5q31-q33 and 11q13 in African American families. Objectives: To clarify relative contributions of these regions to atopy in the same African American population, we have conducted further genetic linkage studies of specific IgE responses toward common inhaled allergens. Methods: We studied 328 individuals in 58 African American families participating in the CSGA, Specific IgE responses toward Dermatophagoides farinae, cat, dog, American cockroach, rye grass, and Bermuda grass,as measured by skin tests, were used for multipoint linkage analysis with polymorphic markers on chromosomes 5q31-q33 and 11q13. Results: Specific IgE response toward American cockroach showed evidence for linkage to chromosomes 5q31-q33 (P =.0050) and 11q13 (P =.017). Specific IgE response toward dog showed evidence for linkage with chromosome 5q31-q33 (P =.0043). Evidence for linkage with chromosome 11q13 was obtained for specific IgE responses toward Dermatophagoides farinae (P =.012), cat (P =.035), and Bermuda grass (P =.017). The presence of a positive ST response for at least 1 of 30 common allergens showed evidence for linkage to chromosomes 5q31-q33 (P =.017) and 11q13 (P =.00058). Conclusions: These data support that genes on both chromosomes 5q31-q33 and 11q13 confer susceptibility to upregulated IgE-mediated immune responses in this African American population. The putative genes on chromosomes 5q31-q33 and 11q13, however, showed contrasting effects on atopy, which may result from strong gene-environmental interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:10:59