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Titolo:
HPV-16 AND CIGARETTE-SMOKING AS RISK-FACTORS FOR HIGH-GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA
Autore:
HO GYF; KADISH AS; BURK RD; BASU J; PALAN PR; MIKHAIL M; ROMNEY SL;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT EPIDEMIOL & SOCIAL MED,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10461
Titolo Testata:
International journal of cancer
fascicolo: 3, volume: 78, anno: 1998,
pagine: 281 - 285
SICI:
0020-7136(1998)78:3<281:HACARF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS INFECTION; INTRAEPITHELIAL NEOPLASIA; BETA-CAROTENE; WOMEN; DYSPLASIA; CANCER; SMOKERS; PLASMA; MUCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G.Y.F. Ho et al., "HPV-16 AND CIGARETTE-SMOKING AS RISK-FACTORS FOR HIGH-GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA", International journal of cancer, 78(3), 1998, pp. 281-285

Abstract

Although genital human papillomavirus (HPV) infection is well established as the etiologic agent for cervical intraepithelial neoplasia (CIN), little is known about the cofactors involved in the development ofhigh-grade lesions or the progression of low-grade to high-grade lesions. In our study of HPV-infected women with CIN (163 CIN I, 51 CIN IIand 44 CIN III), women with CIN II or III were compared with those with CIN I for risk factors associated with high-grade lesions. After controlling for age, education, ethnicity and frequency of Pap smear screening, infection with HPV 16, but not high viral load or infection with multiple types, was associated with high-grade lesions (OR for CIN II = 11.96, OR for CIN III = 23.74). Risk of CIN III, but not CIN II, increased with number of cigarettes smoked per day (ORs = 1.49 and 3.35 for less than or equal to 10 and > 10 cigarettes per day, respectively) and decreased with frequency of condom use during sex (ORs = 0.60 and 0.32 for women who used condoms occasionally/sometimes and most! all of the time, respectively). There were no associations between high-grade lesions and plasma levels of micronutrients (retinol, p-carotene, alpha-tocopherol and reduced ascorbic acid). Our results indicate that infection with HPV 16 is associated with high-grade lesions. Additional cofactors, such as cigarette smoking, may be required as a carcinogen to advance HPV-infected cells toward neoplastic progression. Int. J. Cancer 78:28 1-285, 1998. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 06:34:32