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Titolo:
RADIATION-FIELDS BACKSCATTERED FROM MATERIAL INTERFACES - I - BIOLOGICAL EFFECTIVENESS
Autore:
ZELLMER DL; CHAPMAN JD; STOBBE CC; XU F; DAS IJ;
Indirizzi:
MERCY HOSP,DEPT MED PHYS SCRANTON PA 18501 FOX CHASE CANC CTR,DEPT RADIAT ONCOL PHILADELPHIA PA 19111
Titolo Testata:
Radiation research
fascicolo: 4, volume: 150, anno: 1998,
pagine: 406 - 415
SICI:
0033-7587(1998)150:4<406:RBFMI->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRASOFT X-RAYS; CHINESE-HAMSTER CELLS; MAMMALIAN-CELLS; IONIZING-RADIATION; SENSITIVE MUTANTS; SURVIVAL CURVES; TRACK STRUCTURE; DOSE-RATE; INACTIVATION; RADIOBIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Zellmer et al., "RADIATION-FIELDS BACKSCATTERED FROM MATERIAL INTERFACES - I - BIOLOGICAL EFFECTIVENESS", Radiation research, 150(4), 1998, pp. 406-415

Abstract

Confluent cultures of CHO-K1 and CHO-xrs5 cells were irradiated attached to 6 mu m Mylar with Cs-137 gamma rays and 200 kVp X rays adjacentto scattering materials consisting of polystyrene, glass, aluminum, copper, tin and lead. The absorbed dose in cell nuclei was estimated from measurements of backscattered dose made with a parallel-plate ion chamber with a 5-mu m Mylar window and a gas volume whose thickness wasequivalent to similar to 2.6 pm of cells or tissue. Cell inactivationafter various doses was measured by clonogenic assays after trypsinization and enumeration. Survival curves constructed from data pooled from at least two independent experiments were best fitted to a linear-quadratic (LQ) or a linear equation for CHO-K1 and CHO-xrs5 cells, respectively. An average distance of 9.3 +/- 1.9 mu m from the scattering surfaces to the midline of nuclei for both the cell lines was estimated from electron micrographs of fixed cell sections. The major differences in biological effect observed when the cells were irradiated adjacent to these materials could be largely explained by the differences in the physical dose. Further analyses using the LQ equation suggested additional biological effects with implications for the mechanisms involved. CHO-K1 cells showed a small but consistent increase in the low-dose (alpha-inactivation coefficient) mechanism for both radiations scattered from high-Z material. An increased value of the alpha coefficient suggests an increase in RBE which could be associated with a higher proportion of low-energy and track-end electrons in these fields. The radiation fields which produced maximum single-hit killing in CHO-KIcells also produced less killing by the quadratic (beta-inactivation coefficient) mechanism. In contrast, when similarly irradiated, CHO-xrs5 cells exhibited significantly lower alpha coefficients of inactivation. The mechanistic basis for this opposite effect of backscattered radiations in these cell lines is as yet unknown. (C) 1998 by RadiationResearch Society.

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Documento generato il 05/07/20 alle ore 07:07:18