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Titolo:
STRONG SYNERGISM BETWEEN GABA(A) AND GLYCINE RECEPTORS ON ISOLATED CARP 3RD-ORDER NEURONS
Autore:
LI P; YANG XL;
Indirizzi:
CHINESE ACAD SCI,SHANGHAI INST PHYSIOL,320 YUE YANG RD SHANGHAI 200031 PEOPLES R CHINA CHINESE ACAD SCI,SHANGHAI INST PHYSIOL SHANGHAI 200031 PEOPLES R CHINA CHINESE ACAD SCI,KEY LAB NEUROBIOL SHANGHAI 200031 PEOPLES R CHINA
Titolo Testata:
NeuroReport
fascicolo: 12, volume: 9, anno: 1998,
pagine: 2875 - 2879
SICI:
0959-4965(1998)9:12<2875:SSBGAG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GOLDFISH RETINA; GANGLION-CELLS; AMACRINE CELLS; CHANNELS; PATHWAYS; SYNAPSES;
Keywords:
GABA(A) RECEPTOR; GLYCINE RECEPTOR; RECEPTOR-RECEPTOR INTERACTION; RETINAL 3RD-ORDER NEURON; SYNERGISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P. Li e X.L. Yang, "STRONG SYNERGISM BETWEEN GABA(A) AND GLYCINE RECEPTORS ON ISOLATED CARP 3RD-ORDER NEURONS", NeuroReport, 9(12), 1998, pp. 2875-2879

Abstract

A strong synergistic interaction between the bicuculline-sensitive GABA receptor (GABA(A) receptor) and the strychnine-sensitive glycine receptor was observed in third-order neurons acutely isolated from crucian carp retina, with the use of the whole-cell patch-clamp recording technique. In 58 of 153 cells, 10 mu M GABA or glycine separately applied to amacrine/ganglion cells failed to induce any responses or only induced small currents (<20 pA), while co-application of these two chemicals resulted in much larger responses (403.05 +/- 319.98 pA). The current induced by the co-application was mediated by chloride channels,and both GABA(A) and glycine receptors were involved in the potentiation. The underlying mechanisms of this interaction and its possible physiological role are discussed. (C) 1998 Lippincott Williams & Wilkins.

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Documento generato il 29/03/20 alle ore 15:17:03