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Titolo:
DEVELOPMENT OF GLYCINERGIC TRANSMISSION IN ORGANOTYPIC CULTURES FROM AUDITORY BRAIN-STEM
Autore:
EHRLICH I; ILIC V; LOHMANN C; FRIAUF E;
Indirizzi:
UNIV FRANKFURT KLINIKUM,ZENTRUM PHYSIOL,THEODOR STERN KAI 7 D-60590 FRANKFURT GERMANY
Titolo Testata:
NeuroReport
fascicolo: 12, volume: 9, anno: 1998,
pagine: 2785 - 2790
SICI:
0959-4965(1998)9:12<2785:DOGTIO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; NEURONS; RATS; SYSTEM; FETAL; CLAMP; SOMA;
Keywords:
AUDITORY SYSTEM; GLYCINE RECEPTOR; GLYCINE TRANSPORTER; LATERAL SUPERIOR OLIVE; MEDIAL NUCLEUS OF THE TRAPEZOID BODY; RAT; SUPERIOR OLIVARY COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
I. Ehrlich et al., "DEVELOPMENT OF GLYCINERGIC TRANSMISSION IN ORGANOTYPIC CULTURES FROM AUDITORY BRAIN-STEM", NeuroReport, 9(12), 1998, pp. 2785-2790

Abstract

We investigated whether glycinergic transmission develops organotypically in auditory brain stem cultures. Slices of the medial nucleus of the trapezoid body and the lateral superior olive were incubated in medium with a raised extracellular K<SUP>+</SUP> concentration. As in vivo, glycine receptor alpha 1 subunit immunoreactivity increased and became clustered on somata and proximal dendrites. Together with organotypic expression of glycine transporter GLYT2, this indicates that molecular components of glycinergic synapses form properly. In contrast, glycinergic synaptic currents did not develop as in vivo: after 7 days in vitro they were still similar to those at the time of culture preparation. We suggest that for organotypic development of glycine receptors and transporters, Ca<SUP>2+</SUP> influx due to elevated K<SUP>+</SUP> is sufficient. The development of functional synaptic transmission, however, may require patterned electrical activity. (C)<SUP></SUP> 1998 Lippincott Williams & Wilkins.

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Documento generato il 22/10/20 alle ore 03:35:49