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Titolo:
METHIMAZOLE-INDUCED APLASTIC-ANEMIA IN 3RD EXPOSURE - SUCCESSFUL TREATMENT WITH RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR
Autore:
MEZQUITA P; LUNA V; MUNOZTORRES M; TORRESVELA E; LOPEZRODRIGUEZ F; CALLEJAS JL; ESCOBARJIMENEZ F;
Indirizzi:
PLAZA ISABEL CATOLICA 2,3 GRANADA 18009 SPAIN UNIV HOSP GRANADA,ENDOCRINE UNIT GRANADA SPAIN UNIV HOSP GRANADA,INTERNAL MED UNIT GRANADA SPAIN
Titolo Testata:
Thyroid
fascicolo: 9, volume: 8, anno: 1998,
pagine: 791 - 794
SICI:
1050-7256(1998)8:9<791:MAI3E->2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED AGRANULOCYTOSIS; GRAVES-DISEASE; ANTITHYROID DRUGS; JAPANESE PATIENTS; DOSE REGIMEN; G-CSF; CHEMOTHERAPY; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P. Mezquita et al., "METHIMAZOLE-INDUCED APLASTIC-ANEMIA IN 3RD EXPOSURE - SUCCESSFUL TREATMENT WITH RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR", Thyroid, 8(9), 1998, pp. 791-794

Abstract

The major adverse reactions of antithyroid drugs are hematologic; aplastic anemia (AA) is one of the rarest and most severe complications. Use of recombinant human hemopoietic colony-stimulating factor was reported to be of benefit in patients who developed agranulocytosis, although there is still some doubt regarding the efficacy in AA. We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI). The withdrawal ofMMI and early treatment with 5 mu g/kg per day recombinant human granulocyte colony-stimulating factor (G-CSF) for 9 days, allowed a favorable recovery of peripheral blood cell count. We conclude that the use of hemopoietic colony stimulating factors might be a suitable means toachieve the correction of severe thionamide-induced hematologic adverse reactions.

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Documento generato il 19/01/20 alle ore 10:07:39