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Titolo:
CHARACTERIZATION OF A MAJOR SLOW OSCILLATION IN THE MESENTERIC CIRCULATION OF CONSCIOUS RATS
Autore:
LETIENNE R; JULIEN C; ZHANG ZQ; BARRES C;
Indirizzi:
FAC PHARM LYON,CNRS,ESA 5014,DEPT PHYSIOL & PHARMACOL CLIN,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 10, volume: 25, anno: 1998,
pagine: 820 - 824
SICI:
0305-1870(1998)25:10<820:COAMSO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTENSIVE SYMPATHECTOMIZED RATS; ARTERIAL-PRESSURE LABILITY; RENIN-ANGIOTENSIN SYSTEM; BLOOD-PRESSURE; SPECTRAL-ANALYSIS; HEMODYNAMIC ANALYSIS; NITRIC-OXIDE; LONG EVANS; L-ARGININE; VARIABILITY;
Keywords:
CONSCIOUS RAT; HEMODYNAMICS; N-G-NITRO-L-ARGININE METHYL ESTER; MESENTERIC BLOOD FLOW; SPECTRAL ANALYSIS; SYMPATHECTOMY; SYMPATHETIC NERVOUS SYSTEM; VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R. Letienne et al., "CHARACTERIZATION OF A MAJOR SLOW OSCILLATION IN THE MESENTERIC CIRCULATION OF CONSCIOUS RATS", Clinical and experimental pharmacology and physiology, 25(10), 1998, pp. 820-824

Abstract

1. Little is known about spontaneous slow rhythms in regional circulations. The present study was aimed at characterizing low-frequency (LF; 78-269 mHz) oscillations in the mesenteric and hindquarter circulations of conscious rats. 2, Mean arterial pressure (MAP) and indices (pulsed Doppler technique) of mesenteric (n = 25) and hindquarter (n = 23) blood flows were recorded in conscious, freely moving rats during 1 h periods. Fast Fourier transform analysis was applied to beat-to-beatdata after resampling at 10 Hz of consecutive 205 s time series. 3, Amajor oscillation centred at 164 +/- 4 mHz was present in the mesenteric, but not in hindquarter, circulation. Consequently, LF power accounted for approximately 43% of the overall variability of mesenteric blood flow. Cross-spectral analysis performed between MAP and mesentericblood flow indicated that fractional changes in flow were approximately two-fold of those in MAP, in pressure, at the peak frequency. 4, Acute blockade of the autonomic, renin-angiotensin and vasopressin systems combined with noradrenaline infusion (n = 7) reduced the frequency of the mesenteric blood Bow oscillation (115 +/- 6 mHz) but did not change its contribution to overall flow variability (approximately 48%),A clear oscillation was still present after acute inhibition of nitric oxide (NO) synthesis with N-G-nitro-L-arginine methyl ester (n = 8),but was virtually absent in chronically guanethidine-sympathectomizedrats (n = 12), 5, In conclusion, the mesenteric blood Bow of conscious rats exhibits a major slow oscillation that originates in the mesenteric vasculature and is not secondary to the activity of the major presser systems or to the cyclic release of NO. Because of the strong attenuation of the oscillation in sympathectomized rats, we suggest that adrenergic vasoconstrictor tone plays a permissive role in its genesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:16:25