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Titolo:
MULTIVITAMIN USE, FOLATE, AND COLON-CANCER IN WOMEN IN THE NURSES HEALTH STUDY
Autore:
GIOVANNUCCI E; STAMPFER MJ; COLDITZ GA; HUNTER DJ; FUCHS C; ROSNER BA; SPEIZER FE; WILLETT WC;
Indirizzi:
CHANNING LABS,181 LONGWOOD AVE BOSTON MA 02115
Titolo Testata:
Annals of internal medicine
fascicolo: 7, volume: 129, anno: 1998,
pagine: 517 -
SICI:
0003-4819(1998)129:7<517:MUFACI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM; NEURAL-TUBE DEFECTS; COLORECTAL-CANCER; LOGISTIC-REGRESSION; TRIPHOSPHATE POOLS; ALCOHOL INTAKE; PLASMA FOLATE; FOLIC-ACID; RED-CELL; RISK;
Keywords:
FOLIC ACID; VITAMINS; COLONIC NEOPLASMS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
E. Giovannucci et al., "MULTIVITAMIN USE, FOLATE, AND COLON-CANCER IN WOMEN IN THE NURSES HEALTH STUDY", Annals of internal medicine, 129(7), 1998, pp. 517

Abstract

Background: High intake of folate may reduce risk for colon cancer, but the dosage and duration relations and the impact of dietary compared with supplementary sources are not well understood. Objective: To evaluate the relation between folate intake and incidence of colon cancer. Design: Prospective cohort study. Setting: 88 756 women from the Nurses' Health Study who were free of cancer in 1980 and provided updated assessments of diet, including multivitamin supplement use, from 1980 to 1994. Patients: 442 women with new cases of colon cancer. Measurements: Multivariate relative risk (RR) and 95% CIs for colon cancer inrelation to energy-adjusted folate intake. Results: Higher energy-adjusted folate intake in 1980 was related to a lower risk for colon cancer (RR, 0.69 [95% CI, 0.52 to 0.93] for intake >400 mu g/d compared with intake less than or equal to 200 mu g/d) after controlling for age;family history of colorectal cancer; aspirin use; smoking; body mass;physical activity; and intakes of red meat, alcohol, methionine, and fiber. When intake of vitamins A, C, D, and E and intake of calcium were also controlled for, results were similar. Women who used multivitamins containing folic acid had no benefit with respect to colon cancerafter 4 years of use (RR, 1.02) and had only nonsignificant risk reductions after 5 to 9 (RR, 0.83) or 10 to 14 years of use (RR, 0.80). After 15 years of use, however, risk was markedly lower (RR, 0.25 [CI, 0.13 to 0.51]), representing 15 instead of 68 new cases of colon cancerper 10 000 women 55 to 69 years of age. Folate from dietary sources alone was related to a modest reduction in risk for colon cancer, and the benefit of long-term multivitamin use was present across all levelsof dietary intakes. Conclusions: Long-term use of multivitamins may substantially reduce risk for colon cancer. This effect may be related to the folic acid contained in multivitamins.

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Documento generato il 05/12/20 alle ore 13:04:53