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Titolo:
EFFECT OF ANTIFIBROTIC AGENT SILYMARIN ON LIVER-CELL REGENERATION IN A RAT MODEL OF SECONDARY BILIARY FIBROSIS - A MORPHOMETRIC ANALYSIS
Autore:
BOIGK G; HERBST H; JIA JD; RIECKEN EO; SCHUPPAN D;
Indirizzi:
UNIV ERLANGEN NURNBERG,MED KLIN 1,KRANKENHAUSSTR 12 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,MED KLIN 1 D-91054 ERLANGEN GERMANY FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT GASTROENTEROL & HEPATOL D-12200 BERLIN GERMANY UNIV HAMBURG,HOSP EPPENDORF,INST PATHOL D-20246 HAMBURG GERMANY CAPITAL UNIV,BEIJING FRIENDSHIP HOSP,LIVER RES CTR BEIJING PEOPLES R CHINA
Titolo Testata:
PTR. Phytotherapy research
, volume: 12, anno: 1998, supplemento:, 1
pagine: 42 - 44
SICI:
0951-418X(1998)12:<42:EOAASO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
III-PEPTIDE; COLLAGEN ACCUMULATION; CIRRHOSIS; SILIBININ;
Keywords:
LIVER FIBROSIS; CIRRHOSIS; ANTIFIBROTIC DRUG; ANTIFIBROTIC AGENT; LIVER CELL REGENERATION; MITOSIS; EXPERIMENTAL MODEL; SERUM MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
G. Boigk et al., "EFFECT OF ANTIFIBROTIC AGENT SILYMARIN ON LIVER-CELL REGENERATION IN A RAT MODEL OF SECONDARY BILIARY FIBROSIS - A MORPHOMETRIC ANALYSIS", PTR. Phytotherapy research, 12, 1998, pp. 42-44

Abstract

Silymarin (SIL), a standardized plant extract containing about 60% ofthe polyphenol silibinin, is used as a hepatoprotective agent. In order to explore the effect of SIL on liver cell regeneration in a model of progressive biliary liver fibrosis this substance was applied to adult Wistar rats that were subjected to complete bile duct occlusion (BDO) by injection of the sclerosant sodium amidotrizoate (ethibloc(R)). Rats with sham-operation that received SIL at an oral dose of 50 mg/kg per day (n = 10) and rats with BDO alone (n = 20) served as controls, whereas groups of 20 animals were given SIL at a dose of 25 and 50 mg/kg during weeks 1-6 or of 50 mg/kg during weeks 4-6 of BDO. Animals were killed after 6 weeks. Except for a lower liver weight, total collagen content and histological fibrosis score in the groups that were treated with SIL at 50 mg/kg over 3 or 6 weeks, the number, size and mitotic rate (per microscopic field) of hepatocytes was not different among all groups with BDO. We conclude that SIL had only a minor (macroscopic) effect on the parenchymal compartment, (C) 1998 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:53:17