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Titolo:
CONSISTENT REPEATED M-WAVE AND H-WAVE RECORDING IN THE HIND-LIMB OF RATS
Autore:
CLIFFER KD; TONRA JR; CARSON SR; RADLEY HE; CAVNOR C; LINDSAY RM; BODINE SC; DISTEFANO PS;
Indirizzi:
REGENERON PHARMACEUT INC,777 OLD SAW MILL RIVER RD TARRYTOWN NY 10591
Titolo Testata:
Muscle & nerve
fascicolo: 11, volume: 21, anno: 1998,
pagine: 1405 - 1413
SICI:
0148-639X(1998)21:11<1405:CRMAHR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CISPLATIN-INDUCED NEUROTOXICITY; NERVE-CONDUCTION; DIABETIC RATS; SENSORY NEUROPATHY; REFLEX; ORG-2766; MOTOR; PROTECTION; VELOCITIES; LATENCY;
Keywords:
M WAVE; H REFLEX; NEUROPATHY; CONDUCTION VELOCITY; MOTOR; SENSORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
K.D. Cliffer et al., "CONSISTENT REPEATED M-WAVE AND H-WAVE RECORDING IN THE HIND-LIMB OF RATS", Muscle & nerve, 21(11), 1998, pp. 1405-1413

Abstract

Sensory and motor conduction velocities calculated from latencies of H reflexes and M waves in rat hind limbs have been used to assess experimental peripheral neuropathy. Amplitudes and latencies vary with recording location, and are seldom assessed directly. Using subcutaneous electrodes on the foot, we recorded consistent M waves and H reflexes while stimulating the sciatic or tibial nerve. The late wave disappeared when dorsal roots were cut, verifying that it was an H reflex, However, stimulus-response characteristics differed from those in humans: (a) the threshold was often higher than for M waves; (b) stimulus intensity eliciting a maximum H-reflex amplitude (H-max) was often higher than adequate for a maximum M-wave amplitude; and (c) the amplitudes of H reflexes stimulated with intensities supramaximal for the M wave were over 90% of H-max. H reflexes and M waves recorded repeatedly in rats can be useful in assessing sensory and motor function in models ofneuropathy, using amplitudes as well as conduction velocities. (C) 1998 John Wiley & Sons, Inc. Muscle Nerve 21: 1405-1413, 1998.

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Documento generato il 02/07/20 alle ore 22:02:34