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Titolo:
NON-NMDA AND NMDA RECEPTORS IN THE SYNAPTIC PATHWAY BETWEEN AREA POSTREMA AND NUCLEUS-TRACTUS-SOLITARIUS
Autore:
AYLWIN ML; HOROWITZ JM; BONHAM AC;
Indirizzi:
UNIV CALIF DAVIS,DIV CARDIOVASC MED,DEPT PHARMACOL,TB 172 1 SHIELDS AVE DAVIS CA 95616 UNIV CALIF DAVIS,DIV CARDIOVASC MED,DEPT PHARMACOL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT NEUROBIOL PHYSIOL & BEHAV DAVIS CA 95616
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 4, volume: 44, anno: 1998,
pagine: 1236 - 1246
SICI:
0363-6135(1998)44:4<1236:NANRIT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS; RAT; VASOPRESSIN; CELLS; PROJECTIONS; STIMULATION; BRAIN; LOCALIZATION; TRANSMISSION; CONNECTIONS;
Keywords:
SYNAPTIC TRANSMISSION; VOLTAGE CLAMP; AUTONOMIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Aylwin et al., "NON-NMDA AND NMDA RECEPTORS IN THE SYNAPTIC PATHWAY BETWEEN AREA POSTREMA AND NUCLEUS-TRACTUS-SOLITARIUS", American journal of physiology. Heart and circulatory physiology, 44(4), 1998, pp. 1236-1246

Abstract

Area postrema (AP) modulates cardiovascular function through excitatory projections to neurons in nucleus tractus solitarius (NTS), which also process primary sensory (including cardiovascular-related) input via the solitary tract (TS). The neurotransmitter(s) and their receptors in the AP-NTS pathway have not been fully characterized. We used whole cell recordings in voltage- and current-clamp modes in the rat brain stem slice to examine the role of ionotropic glutamatergic receptorsand alpha(2)-adrenergic receptors in the pathway from AP to NTS neurons receiving visceral afferent information via the TS. In neurons voltage clamped at potentials from -100 to +80 mV,AP stimulation (0.2 Hz) evoked excitatory postsynaptic currents having a fast component blocked by the non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxobenzo- quinoxaline-7-sulfonamide (NBQX; 3 mu M, n = 7) and a slow component blocked by the NMDA receptor antagonist DL-2-amino-5-phosphonovaleric acid (APV; 50 mu M, n = 8). Although NBQX (3 mu M, n = 14) abolished AP-evoked action potentials, APV (50 mu M, n = 9 or 500 mu M, n = 6) or yohimbine, (200 nM, n = 5 or 2 mu M,n = 10) did not. Thus, although AP stimulation activates both non-NMDA and NMDA receptors on NTS neurons receiving TS input, only non-NMDA receptors are required for synaptic transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:01:58