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Titolo:
EVALUATION OF THE ABBOTT SYSTEM IN MATERNAL SERUM SCREENING FOR DOWN-SYNDROME - THE AXSYM ANALYZER, AFP AND HCG REAGENTS AND MACIEL PRENATAL INTERPRETIVE SOFTWARE
Autore:
MULLER F; NGO S; AEGERTER P; LEBOURDELLES S; TAGUEL V; REBIFFE M; FAINA S; GIRAUDET P;
Indirizzi:
HOP AMBROISE PARE,BIOCHIM LAB BOULOGNE FRANCE HOP AMBROISE PARE,SERV BIOSTAT BOULOGNE FRANCE
Titolo Testata:
Clinica chimica acta
fascicolo: 1, volume: 277, anno: 1998,
pagine: 65 - 75
SICI:
0009-8981(1998)277:1<65:EOTASI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-FETOPROTEIN; CHORIO-GONADOTROPIN; BETA-SUBUNIT; CHORIOGONADOTROPIN; ASSAYS; FETAL; PREGNANCIES; MULTIPLE; RISK;
Keywords:
TRISOMY 21; MATERNAL SERUM MARKERS; RISK EVALUATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
F. Muller et al., "EVALUATION OF THE ABBOTT SYSTEM IN MATERNAL SERUM SCREENING FOR DOWN-SYNDROME - THE AXSYM ANALYZER, AFP AND HCG REAGENTS AND MACIEL PRENATAL INTERPRETIVE SOFTWARE", Clinica chimica acta, 277(1), 1998, pp. 65-75

Abstract

Multi-marker maternal serum screening for Down syndrome in the secondtrimester is now part of routine care in many centers. Most protocolsuse a combination of hCG (or its free beta-subunit) and cc-fetoprotein (AFP) or unconjugated estriol (UE3), or both. Risk calculation is based on these maternal serum marker values combined with maternal age and trisomy 21 maternal age-related risk. Computer programs are therefore necessary. Both technical and statistical efficiency are included in the final risk evaluation. We studied the Abbott system, comprising AxSym analyzer, AFP and hCG kits and Prenatal Interpretive Software (Maciel). Median values were established between 14 and 18 weeks of amenorrhea in a population of 1822 patients and in twin pregnancies in 157cases. Forty maternal sera from trisomy 21 affected pregnancies were analyzed, Software was evaluated in a population of 429 patients and in 124 cases of trisomy 21. We conclude that this system constitutes anaccurate and efficient method of maternal serum screening for Down syndrome. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:18:55