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Titolo:
FACTOR DETERMINING CARDIAC-HYPERTROPHY IN HYPERTENSIVE PATIENTS WITH OR WITHOUT PERIPHERAL VASCULAR-DISEASE
Autore:
BRAHIMI M; LEVY BI; SAFAR ME; DABIRE H;
Indirizzi:
HOP BROUSSAIS,SERV MED INTERNE 1,96 RUE DIDOT F-75014 PARIS FRANCE HOP BROUSSAIS,SERV MED INTERNE 1 F-75014 PARIS FRANCE HOP LARIBOISIERE F-75475 PARIS 10 FRANCE
Titolo Testata:
Clinical science
fascicolo: 3, volume: 95, anno: 1998,
pagine: 261 - 267
SICI:
0143-5221(1998)95:3<261:FDCIHP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIOSCLEROSIS OBLITERANS; ARTERIAL-DISEASE; PULSE PRESSURE; LOWER-LIMBS;
Keywords:
CARDIAC HYPERTROPHY; HYPERTENSION; PERIPHERAL VASCULAR DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
M. Brahimi et al., "FACTOR DETERMINING CARDIAC-HYPERTROPHY IN HYPERTENSIVE PATIENTS WITH OR WITHOUT PERIPHERAL VASCULAR-DISEASE", Clinical science, 95(3), 1998, pp. 261-267

Abstract

1. Coronary ischaemic disease and congestive heart failure are the principal causes of mortality in patients with peripheral vascular disease. Whether cardiac hypertrophy is present and even more pronounced inperipheral vascular disease than in other populations has never been explored. 2. Twenty-five hypertensive patients were investigated, 11 without and 14 with peripheral vascular disease, matched for age, sex, mean arterial pressure and antihypertensive drug treatment. Cardiac mass was determined using echocardiography together with measurement of systemic blood pressure, ratio between ankle systolic pressure (ASP) and brachial systolic pressure (BSP), and standard biochemical parameters including natriuresis per 24 h. 3. At the same mean arterial pressure, patients with peripheral vascular disease had a significantly higher cardiac mass (157+/-12 versus 116+/-6 g/m(2); P < 0.01), pulse pressure (81 +/- 5 versus 55+/-4 mmHg; P < 0.01) and natriuresis (180 +/- 17 versus 144+/-6 mmol/24 h; P < 0.01) than controls. Using univariatecorrelations, cardiac mass was positively associated with pulse pressure, mean arterial pressure and natriuresis, and negatively with the ASP/BSP ratio. On the basis of multivariate regression analysis, only natriuresis was positively correlated to cardiac mass. 4. Patients withperipheral vascular disease develop a higher degree of cardiac hypertrophy in comparison with hypertensive subjects with the same level of mean arterial pressure. Sodium intake rather than mechanical factors seems to be the major modulating factor which influences the degree of cardiac hypertrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:47:21