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Titolo:
CRUCIAL ROLE FOR 5-HT IN CHOLERA-TOXIN BUT NOT ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN-INTESTINAL SECRETION IN RATS
Autore:
TURVILL JL; MOURAD FH; FARTHING MJG;
Indirizzi:
ST BARTHOLOMEWS & ROYAL LONDON SCH MED & DENT,DIGEST DIS RES CTR,TURNER ST LONDON E1 2AD ENGLAND
Titolo Testata:
Gastroenterology
fascicolo: 4, volume: 115, anno: 1998,
pagine: 883 - 890
SICI:
0016-5085(1998)115:4<883:CRF5IC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROLYTE TRANSPORT; FLUID SECRETION; RECEPTOR ANTAGONIST; DIARRHEAL DISEASE; VIBRIO-CHOLERAE; 5-HYDROXYTRYPTAMINE; GRANISETRON; TRACT; ACID; CATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Turvill et al., "CRUCIAL ROLE FOR 5-HT IN CHOLERA-TOXIN BUT NOT ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN-INTESTINAL SECRETION IN RATS", Gastroenterology, 115(4), 1998, pp. 883-890

Abstract

Background & Aims: Many consider cholera toxin (CT) and Escherichia coil heat-labile enterotoxin (LT) to be functionally identical. Both increase intracellular adenosine 3',5'-cyclic monophosphate concentration; however, differences between the two and the severity of the diseases they cause have been reported. The secretagogue 5-hydroxytryptamine(5-HT) is implicated in CT-induced secretion, but its role in LT-induced secretion is unclear. We tested the hypothesis that LT fails to recruit 5-HT in its secretory processes. Methods: In vivo small intestinal perfusions were undertaken in adult male Wistar rats after incubation with equipotent doses of CT or LT, or saline. Small intestinal 5-HTrelease and the effect on net small intestinal water and electrolyte transport of (1) pharmacological depletion of 5-HT; (2) blockade of 5-HT type 2, 3, and 4 receptors; and (3) pretreatment with lidocaine, hexamethonium, and atropine were determined. Results: CT- but not LT-induced secretion was accompanied by 5-HT release, reduced by 5-HT depletion, and inhibited by each 5-HT antagonist. By contrast, lidocaine andhexamethonium inhibited secretion induced by both toxins. Conclusions: LT induces secretion without recruiting a 5-HT-dependent cascade. This may account for differences in clinical severity of the diseases CTand LT cause and has implications for the development of antisecretory therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:11:47