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Titolo:
POSTCARDIOPLEGIC MYOCARDIAL RECOVERY - EFFECTS OF HALOTHANE, NIFEDIPINE, HOE-694, AND QUINACRINE
Autore:
LOCHNER A; GENADE S; TROMP B; THERON S; TROLLIP G;
Indirizzi:
UNIV STELLENBOSCH,FAC MED,DEPT MED PHYSIOL & BIOCHEM,POB 19063 ZA-7505 TYGERBERG SOUTH AFRICA MRC,EXPT BIOL PROGRAMME TYGERBERG SOUTH AFRICA
Titolo Testata:
Cardiovascular drugs and therapy
fascicolo: 3, volume: 12, anno: 1998,
pagine: 267 - 277
SICI:
0920-3206(1998)12:3<267:PMR-EO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-CALCIUM EXCHANGE; CORONARY-ARTERY OCCLUSION; SARCOPLASMIC-RETICULUM; RAT-HEART; VOLATILE ANESTHETICS; INTRACELLULAR CALCIUM; NA+/H+ EXCHANGE; RABBIT HEART; CANINE HEART; INHIBITION;
Keywords:
POSTCARDIOPLEGIC RECOVERY; HALOTHANE; NIFEDIPINE; HOE 694; QUINACRINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A. Lochner et al., "POSTCARDIOPLEGIC MYOCARDIAL RECOVERY - EFFECTS OF HALOTHANE, NIFEDIPINE, HOE-694, AND QUINACRINE", Cardiovascular drugs and therapy, 12(3), 1998, pp. 267-277

Abstract

Halothane has been shown to be a powerful myocardial protectant during normothermic cardioplegic arrest and subsequent reperfusion. In viewof its multiple effects on cellular Ca2+ movements and the role of this ion in ischemia-reperfusion injury, the questions of whether halothane is capable of maximally protecting the heart or whether combination therapy of halothane with other Ca2+ blocking agents may be more effective arose. Therefore, the effects of combination therapy with halothane and a calcium antagonist (nifedipine), or a Na+/H+ inhibitor (HOE694), or a Na+/Ca2+ inhibitor (quinacrine) on postcardioplegic functional recovery were evaluated. The isolated perfused rat heart subjected to 45 minutes normothermic cardiac arrest was used as an experimental model. Dose-response curves were pet-formed for each drug. Using theoptimal dosage for each drug, the following results were obtained: (1) Nifedipine (10(-7) M; administered retrogradely 10 minutes before and after cardioplegia) and halothane (1.5% administered during cardioplegia), when administered separately, improved functional recovery. Combination therapy did not further improve protection. (2) HOE 694 (10(-7) M) or quinacrine (10(-9) M) improved post-cardioplegic functional recovery when added for 2 minutes at the onset of reperfusion. Simultaneous administration of HOE 694 and 1.5% halothane was the only combination that yielded additive protection. (3) Quinacrine, a phospholipaseand Na+/Ca2+ exchanger inhibitor, appeared to be the most powerful drug used. In summary, the results obtained indicate that interventions aimed at preventing intracellular Ca2+ overload improve recovery aftercardioplegic arrest. The beneficial effects of halothane could be further improved by HOE 694.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:20:35