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Titolo:
HLA-CW ALLELES ASSOCIATED WITH HLA EXTENDED HAPLOTYPES AND C2 DEFICIENCY
Autore:
CLAVIJO OP; DELGADO JC; AWDEH ZL; FICI D; TURBAY D; ALPER CA; TRUEDSSON L; YUNIS EJ;
Indirizzi:
DANA FARBER CANC INST,DEPT CANC IMMUNOL & AIDS,1 JIMMY FUND WAY BOSTON MA 02115 DANA FARBER CANC INST,DEPT CANC IMMUNOL & AIDS BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PATHOL BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT PATHOL BOSTON MA 02115 CTR BLOOD RES BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PEDIAT BOSTON MA 02115 LUND UNIV,DEPT MED MICROBIOL,CLIN IMMUNOL SECT LUND SWEDEN
Titolo Testata:
Tissue antigens
fascicolo: 3, volume: 52, anno: 1998,
pagine: 282 - 285
SICI:
0001-2815(1998)52:3<282:HAAWHE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; CLOZAPINE-INDUCED AGRANULOCYTOSIS; DIFFERENT ETHNIC-GROUPS; MHC HAPLOTYPES; B-REGION; COMPLOTYPES; VARIANTS; GENES; DNA; POLYMORPHISMS;
Keywords:
C2 DEFICIENCY; EXTENDED HAPLOTYPES; HLA-CW ALLELES; MHC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
O.P. Clavijo et al., "HLA-CW ALLELES ASSOCIATED WITH HLA EXTENDED HAPLOTYPES AND C2 DEFICIENCY", Tissue antigens, 52(3), 1998, pp. 282-285

Abstract

There are four NMC-linked complement genes, BE C2, C4A and C4B, that are inherited as single DNA units, known as complotypes. Extended haplotypes were initially defined by studying the distribution of complotypes in relation to HLA-B and HLA-DR loci in Caucasian families. In order to analyze the distribution of HLA-Cw alleles in relation to extended haplotypes, we studied a large panel of MHC homozygous and hetero zygous cell lines representing previously described Caucasian derived extended haplotypes and 14 patients with complete C2 deficiency. HLA alleles were assigned using sequence-specific oligonucleotide probe hybridization (SSOP). Family analysis served to assign haplotypes for heterozygous samples. We found distinctive HLA-Cw alleles for each independent extended haplotype. Their association in each instance was statistically significant. All patients with C2 deficiency carrying the haplotype [HLA-B18, S042, DR2] were associated with HLA-Cw1203. These conserved allelic combinations may become an important tool for the studyof human evolution and may contribute to the expeditious selection ofprospective donors in clinical transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:21:24