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Titolo:
USE OF A PLACEBO IN CLINICAL-TRIALS
Autore:
EMILIEN G; MALOTEAUX JM; SEGHERS A; CHARLES G;
Indirizzi:
127 RUE HENRI PROU F-78340 LES CLAYES BOIS FRANCE CATHOLIC UNIV LOUVAIN,CLIN UNIV ST LUC,DEPT NEUROL B-1200 BRUSSELS BELGIUM CATHOLIC UNIV LOUVAIN,CLIN UNIV ST LUC,DEPT PSYCHIAT B-1200 BRUSSELS BELGIUM CATHOLIC UNIV LOUVAIN,CLIN UNIV ST LUC,PHARMACOL LAB B-1200 BRUSSELS BELGIUM
Titolo Testata:
European psychiatry
fascicolo: 5, volume: 13, anno: 1998,
pagine: 254 - 263
SICI:
0924-9338(1998)13:5<254:UOAPIC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; HEALTHY-VOLUNTEERS; SOCIAL PHOBIA; PHASE-I; DEPRESSION; ANTIDEPRESSANT; DRUGS; TRUE;
Keywords:
PLACEBO; CLINICAL TRIAL; METHODOLOGY; NEUROPSYCHIATRIC RESEARCH; NOCEBO REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
G. Emilien et al., "USE OF A PLACEBO IN CLINICAL-TRIALS", European psychiatry, 13(5), 1998, pp. 254-263

Abstract

The use of a placebo control group in the evaluation of a new productis today considered by most as a necessary condition of experimental drug research. Placebo response is an essential consideration in all clinical trials. If not properly controlled, incorrect and dangerous conclusion may be inferred for a product efficacy and safety profile. However, the inclusion of a placebo group in clinical trials in neuropsychiatric research raises several ethical and scientific questions. Whereas in certain indications, such as suicidal patients and severe and psychotic depression, the use of a placebo is generally not accepted, it is difficult to assess drug efficacy. This article discusses the concept of placebo in clinical trials, the occurrence of adverse events after placebo treatment and the high response rate of placebo in neuropsychiatric clinical research. The experimental methodology to adequately control all the factors involved is also analysed and discussed. (C) 1998 Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:47:17