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Titolo:
PHYSIOLOGICAL AND BIOCHEMICAL ADRENERGIC REGULATION OF THE STUNNED MYOCARDIUM
Autore:
VATNER DE; VATNER SE;
Indirizzi:
ALLEGHENY UNIV HLTH SCI,CARDIOVASC & PULM RES INST,ALLEGHENY CAMPUS,15TH FLOOR,S TOWER PITTSBURGH PA 15212
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 186, anno: 1998,
pagine: 131 - 137
SICI:
0300-8177(1998)186:1-2<131:PABARO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENYLYL CYCLASE; INOTROPIC STIMULATION; METABOLIC RESERVE; CORONARY-ARTERY; ISCHEMIA; RECEPTORS; DYSFUNCTION; SENSITIZATION; EPINEPHRINE; REDUCTION;
Keywords:
MYOCARDIAL STUNNING; BETA-ADRENERGIC RECEPTOR; ADENYLYL CYCLASE; CORONARY ARTERY OCCLUSION; CORONARY ARTERY REPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Vatner e S.E. Vatner, "PHYSIOLOGICAL AND BIOCHEMICAL ADRENERGIC REGULATION OF THE STUNNED MYOCARDIUM", Molecular and cellular biochemistry, 186(1-2), 1998, pp. 131-137

Abstract

A dual approach was employed to study beta-adrenergic receptor signaltransduction in post ischemic (stunned) myocardium, examining physiological interventions in awake, chronically instrumented pigs and biochemical, cellular mechanisms in sarcolemmal preparations from the stunned hearts using the contralateral non-ischemic zone as a control. Ten min of coronary artery occlusion (CAO) and 30 min coronary artery reperfusion (CAR) resulted in depressed posterior wall-thickening (myocardial stunning). Isoproterenol increased transmural wall thickening morein stunned myocardium than in non-ischemic myocardium. In contrast, the responses of wall thickening to forskolin, actually decreased during stunning compared with control. NKH 477, a water soluble forskolin derivative, that does not activate cardiac nerves, increased wall thickening in non-ischemic tissue similarly to the effects on stunned myocardium. Increasing cardiac neural tone reflexly with inferior venal caval occlusion (IVCO) elicited similar results to forskolin, i.e., stunned myocardium responded with less of an increase in wall thickening ascompared with non-ischemic myocardium. beta-adrenergic receptor density, as determined with I-125-cyanopindolol binding, was significantly increased in stunned subendocardium and subepicardium compared with respective values in non-ischemic myocardium. There were no differences in the response of adenylyl cyclase to isoproterenol in stunned and non-ischemic myocardium. The enhanced responsiveness of the beta-adrenergic receptor to isoproterenol stimulation in stunned myocardium corresponded to the increase in beta-adrenergic receptor density. The combination of enhanced responses to isoproterenol, and decreased responses to forskolin and to IVCO and preserved responsiveness to NKH 477, suggest that stunned myocardium is characterized by transient sympathetic neural stunning. The enhanced sensitivity to beta-adrenergic receptor stimulation has important clinical implications, both in terms of therapy of stunned myocardium and detection of stunned and /or hibernatingmyocardium, i.e., low dose dobutamine echocardiography.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:13:20