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Titolo:
RAPID PACING-INDUCED PRECONDITIONING IS RECAPTURED BY FARNESOL TREATMENT IN HEARTS OF CHOLESTEROL-FED RATS - ROLE OF POLYPRENYL DERIVATIVESAND NITRIC-OXIDE
Autore:
FERDINANDY P; CSONKA C; CSONT T; SZILVASSY Z; DUX L;
Indirizzi:
ALBERT SZENT GYORGYI MED UNIV,DEPT BIOCHEM,POB 415 H-6701 SZEGED HUNGARY ALBERT SZENT GYORGYI MED UNIV,DEPT MED 1 H-6701 SZEGED HUNGARY
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 186, anno: 1998,
pagine: 27 - 34
SICI:
0300-8177(1998)186:1-2<27:RPPIRB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ISCHEMIC MYOCARDIUM; DIETARY-CHOLESTEROL; VASCULAR TOLERANCE; G-PROTEINS; PATHWAY; RABBITS; HYPERCHOLESTEROLEMIA; NITROGLYCERIN; EXPLOITATION;
Keywords:
PACING; PRECONDITIONING; FARNESOL; HIGH-CHOLESTEROL DIET; NITRIC OXIDE; ELECTRON SPIN RESONANCE; RAT HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P. Ferdinandy et al., "RAPID PACING-INDUCED PRECONDITIONING IS RECAPTURED BY FARNESOL TREATMENT IN HEARTS OF CHOLESTEROL-FED RATS - ROLE OF POLYPRENYL DERIVATIVESAND NITRIC-OXIDE", Molecular and cellular biochemistry, 186(1-2), 1998, pp. 27-34

Abstract

We have previously shown that hypercholesterolemia leads to the loss of pacing-induced preconditioning (PC), possibly due to the impairmentof cardiac nitric oxide (NO) synthesis. It has been shown that excessexogenous cholesterol inhibits formation of several polyprenyl derivatives involved in signal transduction. In the present study, we examined whether PC and cardiac NO synthesis are restored by treatment with the key polyprenyl product, farnesol, in cholesterol-fed rats. Rats fed 2% cholesterol-enriched/control diet for 24 weeks were given i.p. 5 mu M/kg farnesol/vehicle, respectively An hour later, hearts were isolated and prepared for 'working' perfusion, then subjected to PC/non-PCprotocols of 3 intermittent periods of pacing of 5 min duration at 10Hz, followed by a 10 min coronary occlusion to test the effect of PC. PC increased ischemic aortic flow (AF) from its control value of 15.6+/- 1.5 to 27.3 +/- 1.7 mL/min (p < 0.05). PC was not observed in hearts obtained from hypercholesterolemic rats (AF: 15.7 +/- 1.2 mL/min),however, it reappeared in the farnesol-treated hypercholesterolemic group (AF: 31.8 +/- 3.4 mL/ min, p < 0.05). In tissue samples from the left ventricle, cholesterol-diet markedly decreased the intensity of the electron spin resonance spectra of NO obtained after in vivo spin trapping with Fe2+-diethyl-dithio-carbamate complex. Farnesol-treatmentdid not influence cardiac NO content in the cholesterol-fed or in thecontrol group. These results show that the lost PC can be recaptured by farnesol-treatment in hypercholesterolemia, however, farnesol-treatment does not restore cardiac NO synthesis.

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Documento generato il 28/11/20 alle ore 00:09:28