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Titolo:
NURR1 MESSENGER-RNA EXPRESSION IN NEONATAL AND ADULT-RAT BRAIN FOLLOWING KAINIC ACID-INDUCED SEIZURE ACTIVITY
Autore:
CRISPINO M; TOCCO G; FELDMAN JD; HERSCHMAN HR; BAUDRY M;
Indirizzi:
UNIV SO CALIF,PROGRAM NEUROSCI,HEDCO NEUROSCI BLDG,ROOM 311 LOS ANGELES CA 90089 UNIV CALIF LOS ANGELES,HLTH SCI CTR,DEPT PEDIAT LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,CTR HLTH SCI,INST MOL BIOL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,CTR HLTH SCI,DEPT MOL & MED PHARMACOL LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,CTR HLTH SCI,DEPT BIOL CHEM LOS ANGELES CA 90095
Titolo Testata:
Molecular brain research
fascicolo: 2, volume: 59, anno: 1998,
pagine: 178 - 188
SICI:
0169-328X(1998)59:2<178:NMEINA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE RECEPTOR SUPERFAMILY; MESSENGER-RNA EXPRESSION; TEMPORAL-LOBE EPILEPSY; NERVE GROWTH-FACTOR; DAMAGE SYNDROME; POSTNATAL-DEVELOPMENT; TRANSCRIPTION FACTOR; ORPHAN RECEPTORS; NEURONAL DAMAGE; NGFI-B;
Keywords:
NURR1; MESSENGER-RNA; KAINIC ACID; SEIZURE; HIPPOCAMPUS; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Crispino et al., "NURR1 MESSENGER-RNA EXPRESSION IN NEONATAL AND ADULT-RAT BRAIN FOLLOWING KAINIC ACID-INDUCED SEIZURE ACTIVITY", Molecular brain research, 59(2), 1998, pp. 178-188

Abstract

Nurr1 is an immediate early gene encoding a member of the steroid-thyroid hormone receptor family. In PC12 cells, Nurr1 is readily induced by membrane depolarization, but not by growth factors. Nurr1 is predominantly expressed in the brain, and is essential to the differentiation of midbrain dopaminergic neurons. However, Nurr1 is also expressed in brain regions unrelated to dopaminergic neurons, e.g., hippocampus and cerebral cortex, and its immediate induction following seizure activity suggests a potential involvement of this transcription factor in modulating gene expression in the nervous system. To investigate the response of Nurr1 to neuronal activation, we analyzed Nurr1 mRNA expression in neonatal and adult rat brain following kainic acid (KA)-induced seizure. In P7 animals, systemic injection of KA increased Nurr1 mRNA levels in a few hilar cells of the dentate gyrus and some pyramidal cells of the CA3 region of the hippocampus. In older animals, Nurr1 induction progressively expanded to all hippocampal regions (P14, P21) and eventually to cortical regions (adult). The increase was rapid and transient in the dentate gyrus, a structure resistant to the neurotoxic effect of KA, and was more prolonged in other regions more susceptible to KA toxicity. Induction of Nurr1 at early postnatal stages and rapid increase in the dentate gyrus following KA-induced seizure, suggest that Nurr1 expression is modulated by neuronal activity. On the other hand, prolonged Nurr1 induction in regions sensitive to KA toxicity indicates a possible involvement of Nurr1 in selective neuronal vulnerability. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:05:13