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Titolo:
BCL-2 ONCOPROTEIN POSITIVITY AND HIGH MIB-1 (KI-67) PROLIFERATIVE RATE ARE INDEPENDENT PREDICTIVE MARKERS FOR RECURRENCE IN PROSTATE CARCINOMA
Autore:
KESHGEGIAN AA; JOHNSTON E; CNAAN A;
Indirizzi:
BRYN MAWR HOSP,DEPT PATHOL,130 S BRYN MAWR AVE BRYN MAWR PA 19010 BRYN MAWR HOSP,JOHN S SHARPE RES FDN BRYN MAWR PA 19010 CHILDRENS HOSP PHILADELPHIA,DEPT PEDIAT,DIV BIOSTAT & EPIDEMIOL PHILADELPHIA PA 19104
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 4, volume: 110, anno: 1998,
pagine: 443 - 449
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53 PROTEIN ACCUMULATION; TUMOR-SUPPRESSOR GENE; CELL NUCLEAR ANTIGEN; IMMUNOHISTOCHEMICAL DETECTION; INTRAEPITHELIAL NEOPLASIA; RADICAL PROSTATECTOMY; RETINOBLASTOMA GENE; CANCER; ADENOCARCINOMA; EXPRESSION;
Keywords:
PROSTATE CANCER; PROGNOSTIC FACTORS; ONCOPROTEINS; CELL PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Keshgegian et al., "BCL-2 ONCOPROTEIN POSITIVITY AND HIGH MIB-1 (KI-67) PROLIFERATIVE RATE ARE INDEPENDENT PREDICTIVE MARKERS FOR RECURRENCE IN PROSTATE CARCINOMA", AJCP. American journal of clinical pathology, 110(4), 1998, pp. 443-449

Abstract

Predicting the clinical behavior of prostate carcinoma can be difficult; one approach is to identify molecular prognostic markers. We evaluated proliferative rate (MIB-1 antibody) and expression of bcl-2, p53,and retinoblastoma (pRB) proteins, which have cell cycle-related functions, in 208 consecutive radical prostatectomy specimens. Values werecorrelated with histopathologic parameters (Gleason tumor score, tumor amount, capsule invasion, and involvement of surgical margins, seminal vesicles, or lymph nodes) and with recurrence-free survival (4-yearmedian follow-up). A high MIB-1 proliferative rate was associated with all of the measured histopathologic parameters, p53 overexpression with tumor amount, and pRB expression with positive lymph nodes. pRB and p53 expression levels were not associated with proliferative rate and bcl-2 positivity were associated with increased recurrence, both considered individually, and also independently and additively when examined together and with the most predictive histopathologic factors (Gleason tumor score and seminal vesicle involvement). MIB-1 proliferativerate and bcl-2 positivity may prove to be useful markers for poor prognosis in prostate carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:37:27