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Titolo:
INHIBITION OF PROTEASOME FUNCTION PREVENTS THYMOCYTE APOPTOSIS - INVOLVEMENT OF ORNITHINE DECARBOXYLASE
Autore:
GRASSILLI E; BENATTI F; DANSI P; GIAMMARIOLI AM; MALORNI W; FRANCESCHI C; DESIDERIO MA;
Indirizzi:
UNIV MILAN,INST GEN PATHOL,VIA L MANGIAGALLI 31 I-20133 MILAN ITALY UNIV MILAN,INST GEN PATHOL I-20133 MILAN ITALY CNR,CTR RES CELL PATHOL I-20133 MILAN ITALY IST SUPER SANITA,LAB ULTRASTRUCT I-00161 ROME ITALY UNIV MODENA,DEPT BIOMED SCI,SECT GEN PATHOL I-41100 MODENA ITALY INRCA ANCONA ANCONA ITALY
Titolo Testata:
Biochemical and biophysical research communications (Print)
fascicolo: 2, volume: 250, anno: 1998,
pagine: 293 - 297
SICI:
0006-291X(1998)250:2<293:IOPFPT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; HISTONE ACETYLTRANSFERASE; RAT THYMOCYTES; TUMOR-CELLS; HEAT-SHOCK; POLYAMINES; ANTIZYME; PROTEIN; GROWTH; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E. Grassilli et al., "INHIBITION OF PROTEASOME FUNCTION PREVENTS THYMOCYTE APOPTOSIS - INVOLVEMENT OF ORNITHINE DECARBOXYLASE", Biochemical and biophysical research communications (Print), 250(2), 1998, pp. 293-297

Abstract

We have previously shown that polyamine levels rapidly decrease in thymocytes undergoing apoptosis, and that ornithine decarboxylase increases early but too transiently to maintain elevated polyamine levels. These data led us to suppose that a precocious ornithine decarboxylase degradation might be responsible for the imbalance of polyamine metabolism. Ornithine decarboxylase is known to be degraded by the cytosolic26S proteasome that plays an essential role in thymocyte apoptosis. In this paper we demonstrate that the inhibition of proteasome functionpreserves ornithine decarboxylase activity and prevents thymocytes from undergoing apoptosis after dexamethasone treatment, Since intracellular polyamine levels are also preserved, ornithine decarboxylase seems to be functionally active in maintaining polyamine homeostasis afterproteasome inhibition in thymocytes. Our proposed role for the proteasome in quiescent cells upon an apoptotic stimulus is to degrade proteins like ornithine decarboxylase that are involved in the control of the cell cycle and cell survival. (C) 1998 Academic Press.

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Documento generato il 01/10/20 alle ore 07:22:57