Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CLOZAPINE, HALOPERIDOL, AND THE D-4 ANTAGONIST PNU-101387G - IN-VIVO EFFECTS ON MESOCORTICAL, MESOLIMBIC, AND NIGROSTRIATAL DOPAMINE AND SEROTONIN RELEASE
Autore:
BRODERICK PA; PIERCEY MF;
Indirizzi:
CUNY,SCH MED,DEPT PHYSIOL & PHARMACOL,RM J910,CONVENT AVE & W 138TH ST NEW YORK NY 10031 CUNY GRAD SCH & UNIV CTR,DEPT BIOL,DOCTORAL PROGRAM NEW YORK NY 10036 CUNY GRAD SCH & UNIV CTR,DEPT PSYCHOL NEW YORK NY 10036 PHARMACIA & UPJOHN INC,CNR RES KALAMAZOO MI 49001
Titolo Testata:
Journal of neural transmission
fascicolo: 6-7, volume: 105, anno: 1998,
pagine: 749 - 767
SICI:
0300-9564(1998)105:6-7<749:CHATDA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; MEDIAL PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; PHARMACOLOGICAL CHARACTERIZATION; INDUCED CATALEPSY; RAT; NEURONS; TERMINALS; INVIVO; AUTORECEPTORS;
Keywords:
NEUROLEPTICS; ANTIPSYCHOTIC AGENTS; EXTRAPYRAMIDAL SYMPTOMS (EPS); MOTOR DISORDERS; SCHIZOPHRENIA; PSYCHOSIS; DOPAMINE RECEPTOR ANTAGONISTS; SEROTONIN RECEPTOR ANTAGONISTS; DOPAMINE; SEROTONIN; PREFRONTAL CORTEX; NUCLEUS ACCUMBENS; CAUDATE PUTAMEN (DORSAL STRIATUM); A(10) NEURAL PATHWAYS; A(9) NEURAL PATHWAYS; IN VIVO MICROVOLTAMMETRY; IN VIVO ELECTROCHEMISTRY; CARBON PASTE MICROELECTRODES; CLOZAPINE; HALOPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Broderick e M.F. Piercey, "CLOZAPINE, HALOPERIDOL, AND THE D-4 ANTAGONIST PNU-101387G - IN-VIVO EFFECTS ON MESOCORTICAL, MESOLIMBIC, AND NIGROSTRIATAL DOPAMINE AND SEROTONIN RELEASE", Journal of neural transmission, 105(6-7), 1998, pp. 749-767

Abstract

With in vivo microvoltammetry, the dopamine (DA) receptor antagonists, clozapine (D-4/D-2), haloperidol (D-2) and the selective D-4 antagonist, PNU-101387G, were evaluated for their effects on DA and serotonin(5-HT) release within A(10) neuronal terminal fields [mesocortical, prefrontal cortex (PFC), mesolimbic, nucleus accumbens, (NAcc)] and within A(9) neuronal terminal fields [nigrostriatal, caudate putamen (CPU)], in chloral hydrate anesthetized rats. Clozapine, which also has 5-HT2 receptor antagonist properties, significantly (p < 0.001) increased DA release within A(10) terminal fields, PFC and NAcc; DA release was not increased by clozapine within A, terminals, CPU. Serotonin release was significantly (p < 0.001) increased by clozapine within A(10) and A(9) terminal fields. Haloperidol significantly (p < 0.001) increased DA release within PFC, dramatically and significantly (p < 0.001) increased DA release within CPU, but not within NAcc; haloperidol had asmall but statistically significant (p < 0.05) increase on 5-HT release within PFC [only at the highest dose studied (2.5 mg/kg)] and within CPU [only at the lowest dose studied 1.0 mg/kg) (p < 0.05)]. The selective D-4 antagonist, PNU-101387G dramatically and significantly (p <0.001) increased DA release within PFC, modestly, but significantly (p < 0.001) increased DA release within CPU. did not alter DA release within NAcc at the lowest dose studied (1.0 mg/kg) and significantly (p< 0.05) decreased DA release within NAcc at the highest dose studied (1.0 mg/kg). The selective D-4 antagonist did not affect 5-HT release within either A(10) or A(9) terminal fields. The present data are discussed in terms of the neurochemistry, antipsychotic activity, and sideeffect profiles of clozapine and haloperidol, in order to provide comparative profiles for a selective D-4 antagonist, PNU-101387G.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:34:57