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Titolo:
CONTACT-DEPENDENT PROTEIN SECRETION IN PORPHYROMONAS-GINGIVALIS
Autore:
PARK Y; LAMONT RJ;
Indirizzi:
UNIV WASHINGTON,SCH DENT,DEPT ORAL BIOL,BOX 357132 SEATTLE WA 98195 UNIV WASHINGTON,SCH DENT,DEPT ORAL BIOL SEATTLE WA 98195
Titolo Testata:
Infection and immunity
fascicolo: 10, volume: 66, anno: 1998,
pagine: 4777 - 4782
SICI:
0019-9567(1998)66:10<4777:CPSIP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTEROPATHOGENIC ESCHERICHIA-COLI; CULTURED EPITHELIAL-CELLS; ARG-GINGIPAIN; SALMONELLA-TYPHIMURIUM; CYSTEINE PROTEINASE; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; BACTEROIDES-GINGIVALIS; MOLECULAR-CLONING; STRUCTURAL CHARACTERIZATION; LYS-GINGIPAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
Y. Park e R.J. Lamont, "CONTACT-DEPENDENT PROTEIN SECRETION IN PORPHYROMONAS-GINGIVALIS", Infection and immunity, 66(10), 1998, pp. 4777-4782

Abstract

Porphyromonas gingivalis can induce its uptake by host epithelial cells; however, the nature and role of the P. gingivalis molecules involved in this invasion process have yet to be determined. In this study, modulation of secreted P, gingivalis proteins following association with gingival epithelial cells was investigated. Western immunoblot analysis showed that contact with epithelial cells or epithelial cell growth media induces P, gingivalis 33277 to secrete several proteins with molecular masses between 35 and 95 kDa. Secretion of the Arg-gingipainand Lys-gingipain proteases was repressed under these conditions. Thecontact-induced secreted protein profile was altered in Arg-gingipain-deficient and Lys-gingipain-deficient mutants, indicating a possible role for these proteases in the secretion pathway. The P, gingivalis contact-dependent protein secretion pathway differs to some extent fromtype III protein secretion pathways in enteric pathogens, as a gene homologous to the invA family genes was not detected in P. gingivalis, The secreted proteins of P, gingivalis may play a role in the interactions of the organism with host cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:39:29