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Titolo:
EFFECTS OF NOREPINEPHRINE ON NMDA-INDUCED NEUROTOXICITY IN CEREBELLARGRANULAR-CELL CULTURE OF RAT PUPS
Autore:
GEPDIREMEN A; SONMEZ S; KIZILTUNC A; IKBAL M; ERMAN F; DUZENLI S;
Indirizzi:
ATATURK UNIV,FAC MED,DEPT PHARMACOL TR-25240 ERZURUM TURKEY ATATURK UNIV,FAC MED,DEPT MED GENET TR-25240 ERZURUM TURKEY ATATURK UNIV,FAC MED,DEPT BIOCHEM TR-25240 ERZURUM TURKEY
Titolo Testata:
Fundamental and clinical pharmacology
fascicolo: 5, volume: 12, anno: 1998,
pagine: 517 - 520
SICI:
0767-3981(1998)12:5<517:EONONN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL RECOVERY; FOREBRAIN ISCHEMIA; LOCUS COERULEUS; BRAIN-DAMAGE; HIPPOCAMPUS; RELEASE; PHARMACOTHERAPY; STIMULATION; INHIBITION; RECEPTORS;
Keywords:
NOREPINEPHRINE; NMDA; LABETALOL; CEREBELLUM; CELL CULTURE; NEUROTOXICITY; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Gepdiremen et al., "EFFECTS OF NOREPINEPHRINE ON NMDA-INDUCED NEUROTOXICITY IN CEREBELLARGRANULAR-CELL CULTURE OF RAT PUPS", Fundamental and clinical pharmacology, 12(5), 1998, pp. 517-520

Abstract

In this study, norepinephrine was tested in 0.1, 1, 10, 25 and 50 mu M doses in 100 mu M NMDA toxicity on cerebellar granular cell culture of rats. NMDA in 100 mu M concentration induced cell death significantly with respect to controls. Death cell population was 1.08 +/- 0.44% in control and 22.15 +/- 2.46% in 100 mu M NMDA (P < 0.0001). None of the norepinephrine concentrations administrated 15 min prior to NMDA was able to reduce death cell scores to control levels. Results were 8.75 +/- 0.83% in 0.1 mu M, 7.0 +/- 1.01% in 1 mu M, 17.25 +/- 1.31% in 10 mu M, 35.5 +/- 1.38% in 25 mu M and 17.9 +/- 1.72% in 50 mu M norepinephrine plus 100 mu M NMDA administrated groups (P < 0.0001 for all with respect to control). Labetalol, as an alpha and beta blocker in 0.5 mu M concentration which was given 15 min prior to norepinephrine was able to block the effects of it. In comparison with 100 mu M NMDA administered group, only low doses of norepinephrine reduced the death cell scores significantly (for 0.1 and 1 mu M norepinephrine plus NMDAgroups; P < 0.0001). For 10 and 50 mu M norepinephrine plus NMDA groups, death cell scores were found statistically insignificant from the NMDA-administered group (P > 0.05 for both) while for the 25 mu M norepinephrine plus NMDA group, the death cell score was found to be statistically increased (P < 0.0001). (C) Elsevier, Paris.

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Documento generato il 21/09/20 alle ore 08:31:21