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Titolo:
SHORT AND UNEXPECTEDLY POTENT 3-PYRROLIDINONE TYPE INHIBITORS OF HIV-1 REPLICATION
Autore:
BOUYGUES M; MEDOU M; CHERMANN JC; CAMPLO M; KRAUS JL;
Indirizzi:
UNIV MEDITERRANEE,FAC SCI LUMINY,LAB CHIM BIOMOL,163 ROUTE LUMINY,CASE 901 F-13288 MARSEILLE FRANCE UNIV MEDITERRANEE,FAC SCI LUMINY,LAB CHIM BIOMOL F-13288 MARSEILLE FRANCE INSERM,U322,UNITE RETROVIRUS & MALAD ASSOCIEES F-13273 MARSEILLE 9 FRANCE
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 6, volume: 33, anno: 1998,
pagine: 445 - 450
SICI:
0223-5234(1998)33:6<445:SAUP3T>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY VIRUS; SYNTHETIC PEPTIDES; PROTEASE; SPECIFICITY; ANTIBODIES; TARGET; CELLS; AIDS; GAG;
Keywords:
3-PYRROLIDINONE; HIV INHIBITOR; PROLINE ISOSTERE; HIV PROTEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M. Bouygues et al., "SHORT AND UNEXPECTEDLY POTENT 3-PYRROLIDINONE TYPE INHIBITORS OF HIV-1 REPLICATION", European journal of medicinal chemistry, 33(6), 1998, pp. 445-450

Abstract

Based on the specific PhePro proteolytic cleavage of the HIV protease, short pseudo-peptides incorporating a 3-pyrrolidinone ring have beensynthesized. Their potencies to inhibit HIV-1 in MT4 cell culture have been evaluated and compared to that of the bioisostere dipeptide BocPhePro. Analogues incorporating an aromatic residue have shown to inhibit HIV-1 infection in MT4 human lymphoid cell with an IC50 ranging from 1 to 10 mu M. Further experiments are in progress to determine their HIV protease inhibition properties. (C) Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:13:37