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Titolo:
ETHANOL ALTERS HORMONE PRODUCTION IN CULTURED HUMAN PLACENTAL TROPHOBLASTS
Autore:
KARL PI; FISHER SE;
Indirizzi:
N SHORE UNIV HOSP,CORNELL UNIV MED COLL,BOAS MARKS BIOMED SCI RES CTR,DEPT PEDIATR MANHASSET NY 11030
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 4, volume: 17, anno: 1993,
pagine: 816 - 821
SICI:
0145-6008(1993)17:4<816:EAHPIC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL ALCOHOL SYNDROME; HUMAN CHORIONIC-GONADOTROPIN; HETEROLOGOUS DESENSITIZATION; NERVOUS-SYSTEM; PREGNANT-WOMEN; ADENOSINE; CELLS; CYTOTROPHOBLASTS; DIFFERENTIATION; TRANSPORT;
Keywords:
ETHANOL; TROPHOBLASTS; HORMONE PRODUCTION; CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P.I. Karl e S.E. Fisher, "ETHANOL ALTERS HORMONE PRODUCTION IN CULTURED HUMAN PLACENTAL TROPHOBLASTS", Alcoholism, clinical and experimental research, 17(4), 1993, pp. 816-821

Abstract

Maternal alcohol abuse during pregnancy can lead to abnormalities in fetal development, including the fetal alcohol syndrome (FAS). Although intrauterine growth retardation is a hallmark of FAS, the pathophysiology is not fully understood. A contributing factor may be altered placental function, which could affect fetal growth and development. As a major endocrine organ during pregnancy, changes in the production ofplacental hormones could affect pregnancy and possibly fetal development. In this study, the effect of continued exposure to ethanol on placental hormone production was examined using cultured human placental trophoblasts. Ethanol exposure involved diffusion of ethanol from the atmosphere into the culture medium. This was refreshed daily, leading to daily peak concentrations of 280 to 300 mg/dl (60-65 mm) at 16 to 24 hr. This ethanol exposure for 2 or 4 days significantly increased the production of human chorionic gonadotropin and progesterone by the cultured trophoblasts. However, ethanol treatment had no effect on human placental lactogen production. Acute stimulation (10 min) of cultured trophoblasts with adenosine (50 mum) normally results in increased production of cyclic adenosine 3',5'-monophosphate (cAMP). With ethanolexposure, adenosine-stimulated cAMP production was significantly elevated relative to that in controls. However, the effect of ethanol on adenosine-stimulated cAMP did not appear to be secondary to chronic alterations in adenosine in the culture medium. Measurement of adenosine in the culture medium revealed no difference in concentration or production between control and ethanol treated groups. Moreover, chronic (24 hr) pretreatment of trophoblasts with 0.2 to 10 muM additional adenosine before acute adenosine stimulation did not alter the cAMP response in either control or ethanol-treated cells. This study demonstrates that ethanol exposure may alter placental production of hormones, specifically those that are cAMP dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:16:46