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Titolo:
QUANTITATIVE REGIONAL BLOOD-VOLUME STUDIES IN RAT MYOCARDIUM IN-VIVO
Autore:
KAHLER E; WALLER C; ROMMEL E; HILLER KH; VOLL S; BROICH A; HU K; SCHNACKERZ KD; BAUER WR; ERTL G; HAASE A;
Indirizzi:
LEHRSTYHL BIOPHYS,INST PHYS D-97074 WURZUG GERMANY UNIV WURZBURG,INST PHYS D-97070 WURZBURG GERMANY UNIV MANNHEIM,MED KLIN MANNHEIM GERMANY
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 4, volume: 40, anno: 1998,
pagine: 517 - 525
SICI:
0740-3194(1998)40:4<517:QRBSIR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GD-DTPA-POLYLYSINE; CONTRAST AGENTS; SPIN-RELAXATION; WATER EXCHANGE; SMALL-VESSEL; ENHANCEMENT; PERFUSION; QUANTIFICATION; T-1; T1;
Keywords:
QUANTITATIVE MRI; RBV; MYOCARDIUM; CONTRAST AGENTS; T-1 IMAGING; ECG TRIGGERING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E. Kahler et al., "QUANTITATIVE REGIONAL BLOOD-VOLUME STUDIES IN RAT MYOCARDIUM IN-VIVO", Magnetic resonance in medicine, 40(4), 1998, pp. 517-525

Abstract

Many pathophysiological processes in the myocardium are in close relation to changes of the regional blood volume and regional myocardial blood flow or perfusion. Only few methods exist to obtain quantitative values for these parameters. Quantitative regional blood volume (RBV) studies in rat myocardium are presented using snapshot fast low angle shot (FLASH) inversion recovery T-1 measurements with two different blood pool contrast agents, gadolinium diethylenetriaminopentaacetic acid (Gd-DTPA) albumin and Gd-DTPA polylysine. In contrast to previous attempts, each snapshot FLASH image acquisition was EGG-triggered under breathhold conditions. To measure relaxation times shorter than a heart cycle, each T-1 sequence was repeated two times with different delays between inversion pulse and first image acquisition. The experimentswere performed on a Bruker Biospec 70/21 using a homogeneous transmitter coil and a circularly polarized surface receiver coil, a special ECG trigger unit, and a respirator that is controlled by the pulse program. Based on a fast exchange model RBV, maps were calculated from therelaxation time maps for different concentrations of the two blood pool contrast agents, A significant dependence of the RBVm values on blood T-1 was found. This is in accordance with a model that has been developed recently relating the dependence of RBVm on T-1 of blood to perfusion. For Gd-DTPA albumin, the application of the model to the experimental data yields realistic values for RBV and perfusion, The values, which are in accordance with literature data, were obtained at highest contrast agent concentrations i.e., lowest relaxation times of blood (ca, 200 ms).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 05:02:56