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Titolo:
LCK-INDEPENDENT INHIBITION OF T-CELL ANTIGEN RESPONSE BY THE HIV GP120
Autore:
GRATTON S; JULIUS M; SEKALY RP;
Indirizzi:
INST RECH CLIN MONTREAL,IMMUNOL LAB,110 AVE PINS OUEST MONTREAL PQ H2W 1R7 CANADA INST RECH CLIN MONTREAL,IMMUNOL LAB MONTREAL PQ H2W 1R7 CANADA MCGILL UNIV,DEPT MED,DIV EXPT MED MONTREAL PQ CANADA UNIV TORONTO,WELLESLEY HOSP,RES INST TORONTO ON M4Y 1J3 CANADA UNIV TORONTO,DEPT IMMUNOL TORONTO ON CANADA UNIV MONTREAL,FAC MED,DEPT MICROBIOL & IMMUNOL MONTREAL PQ H3C 3J7 CANADA
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 7, volume: 161, anno: 1998,
pagine: 3551 - 3556
SICI:
0022-1767(1998)161:7<3551:LIOTAR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-PROTEIN-KINASE; AMINO-TERMINAL DOMAIN; HUMAN LYMPHOCYTES-T; SIGNAL-TRANSDUCTION; ENVELOPE GLYCOPROTEIN; TCR DESENSITIZATION; CYTOPLASMIC DOMAINS; CROSS-LINKING; L3T4 MOLECULE; CD4 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
S. Gratton et al., "LCK-INDEPENDENT INHIBITION OF T-CELL ANTIGEN RESPONSE BY THE HIV GP120", The Journal of immunology (1950), 161(7), 1998, pp. 3551-3556

Abstract

Binding of the HIV envelope glycoprotein gp120 to CD4 inhibits T cellactivation. We have used a murine T cell clone transfected with either wild-type human CD4 or mutated forms of CD4 to characterize the pathways involved in this inhibitory effect of gp120. Ag-induced proliferation of T cell clones transfected with human CD4 was completely inhibited in the presence of gp120, even though stimulation of this clone isindependent of a CD4/MHC class II interaction. In addition, our results demonstrate that the inhibition by gp120 is not due to the sequestration of lck from TCR and does not require activation of lck by gp120. This suggests that CD4 can regulate the initiation of T cell activation independently of its interaction with lck. Moreover, we demonstratethat the nonresponsiveness induced by gp120 can be reversed by soluble CD4 when added early after onset of stimulation and that gp120 exerts its inhibitory effect when cells are in the G(0) greater than or equal to 1 phase of the cell cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:56:57