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Titolo:
MULTIPLE PRIMARY MELANOMAS - ANALYSIS OF 49 CASES
Autore:
SAVOIA P; QUAGLINO P; VERRONE A; BERNENGO MG;
Indirizzi:
UNIV TURIN,DERMATOL CLIN 1,V CHERASCO 23 I-10126 TURIN ITALY UNIV TURIN,DERMATOL CLIN 1 I-10126 TURIN ITALY
Titolo Testata:
Melanoma research
fascicolo: 4, volume: 8, anno: 1998,
pagine: 361 - 366
SICI:
0960-8931(1998)8:4<361:MPM-AO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY CUTANEOUS MELANOMAS; MALIGNANT-MELANOMA; RISK-FACTORS;
Keywords:
MELANOMA; MULTIPLE PRIMARIES; PROGNOSTIC FACTORS; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P. Savoia et al., "MULTIPLE PRIMARY MELANOMAS - ANALYSIS OF 49 CASES", Melanoma research, 8(4), 1998, pp. 361-366

Abstract

Development of multiple primary melanomas is a rare but well recognized disease, with an estimated incidence ranging from 1.75% to 8.5% in several series. The clinical, histological and epidemiological characteristics of 49 patients, identified from 2470 with histologically confirmed melanoma, are described in this study. Thirty-five of these patients had two primary melanomas, 11 had three melanomas and three had four, five and six melanomas, respectively. Diagnosis was concurrent in22 patients (45%); in the remaining cases the median time interval between the first and second melanoma was 22.6 months and the longest interval was 21.5 years. The mean Breslow's thickness decreased significantly (P < 0.001) from the first melanoma to the second and third lesion. The multiple melanoma patients had a higher percentage of subjectsover 70 years of age or with lentigo maligna melanoma than single melanoma patients. The mean follow-up time was 12 years (range 4-23 years). The B-year survival rate from first melanoma excision (83%) does not differ from that of patients with a single melanoma. In conclusion, the presence of multiple primary melanomas does not appear to be a negative prognostic factor; our data show the importance of close follow-up in melanoma patients in order to detect not only metastases, but also subsequent primaries in their earliest phases. (C) 1998 Lippincott Williams & Wilkins.

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Documento generato il 01/12/20 alle ore 19:29:51