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Titolo:
CLEAVAGE AND ACTIVATION OF PROTEINASE-ACTIVATED RECEPTOR-2 ON HUMAN NEUTROPHILS BY GINGIPAIN-R FROM PORPHYROMONAS-GINGIVALIS
Autore:
LOURBAKOS A; CHINNI C; THOMPSON P; POTEMPA J; TRAVIS J; MACKIE EJ; PIKE RN;
Indirizzi:
MONASH UNIV,DEPT BIOCHEM & MOL BIOL CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,DEPT BIOCHEM & MOL BIOL CLAYTON VIC 3168 AUSTRALIA MONASH UNIV,DEPT MED CLAYTON VIC 3168 AUSTRALIA JAGIELLONIAN UNIV,INST MICROBIOL & IMMUNOL KRAKOW POLAND UNIV GEORGIA,DEPT BIOCHEM & MOL BIOL ATHENS GA 30602 UNIV MELBOURNE,DEPT VET SCI PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 435, anno: 1998,
pagine: 45 - 48
SICI:
0014-5793(1998)435:1<45:CAAOPR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR ENDOTHELIAL-CELLS; BACTEROIDES-GINGIVALIS; MOLECULAR-CLONING; THROMBIN RECEPTOR; CYSTEINE PROTEINASES; HUMAN KERATINOCYTES; EXPRESSION; TRYPSIN; PERIODONTITIS; PAR-2;
Keywords:
PROTEINASE-ACTIVATED RECEPTOR; PORPHYROMONAS GINGIVALIS; NEUTROPHIL; GINGIPAIN-R;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A. Lourbakos et al., "CLEAVAGE AND ACTIVATION OF PROTEINASE-ACTIVATED RECEPTOR-2 ON HUMAN NEUTROPHILS BY GINGIPAIN-R FROM PORPHYROMONAS-GINGIVALIS", FEBS letters, 435(1), 1998, pp. 45-48

Abstract

Gingipain-R, the major arginine-specific proteinase from Porphyromonas gingivalis, it causative agent of adult periodontal disease, was found to cleave a model peptide representing the cleavage site of proteinase-activated receptor-2 (PAR-2), a G-protein-coupled receptor found on the surface of neutrophils. The bacterial proteinase was also shown to induce an increase in the intracellular calcium concentration of enzyme-treated neutrophils, most probably due to PAR-2 activation. This response by neutrophils to gingipain-R may be a mechanism for the development of inflammation associated with periodontal disease. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 08:03:09