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Titolo:
TNF-ALPHA CONVERTING-ENZYME (TACE) IS INHIBITED BY TIMP-3
Autore:
AMOUR A; SLOCOMBE PM; WEBSTER A; BUTLER M; KNIGHT CG; SMITH BJ; STEPHENS PE; SHELLEY C; HUTTON M; KNAUPER V; DOCHERTY AJP; MURPHY G;
Indirizzi:
UNIV E ANGLIA,SCH BIOL SCI NORWICH NR4 7TJ NORFOLK ENGLAND CELLTECH LTD SLOUGH SL1 4EN BERKS ENGLAND UNIV CAMBRIDGE,DEPT BIOCHEM CAMBRIDGE CB2 1QW ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 435, anno: 1998,
pagine: 39 - 44
SICI:
0014-5793(1998)435:1<39:TC(IIB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; C-TERMINAL DOMAIN; TISSUE INHIBITOR; MATRIX METALLOPROTEINASES; DISINTEGRIN; PURIFICATION; SPECIFICITY; MECHANISM; CLONING; SURFACE;
Keywords:
METALLOPROTEINASE; DISINTEGRIN METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASES; TUMOR NECROSIS FACTOR; TNF-ALPHA CONVERTING ENZYME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A. Amour et al., "TNF-ALPHA CONVERTING-ENZYME (TACE) IS INHIBITED BY TIMP-3", FEBS letters, 435(1), 1998, pp. 39-44

Abstract

TNF-alpha converting enzyme (TACE; ADAM-17) is a membrane-bound disintegrin metalloproteinase that processes the membrane-associated cytokine proTNF-alpha to a soluble form. Because of its putative involvementin inflammatory diseases, TACE represents a significant target for the design of specific synthetic inhibitors as therapeutic agents. In order to study its inhibition by tissue inhibitors of metalloproteinases(TIMPs) and synthetic inhibitors of metalloproteinases, the catalyticdomain of mouse TACE (rTACE) was overexpressed as a soluble Ig fusionprotein from NS0 cells. rTACE was found to be well inhibited by peptide hydroxamate inhibitors as well as by TIMP-3 but not by TIMP-1, -2 and -4. These results suggest that TIMP-3, unlike the other TIMPs, may be important in the modulation of pathological events in which TNF-alpha secretion is involved. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 10:19:10