Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE ELECTRICAL AND MECHANICAL RESPONSE OF ADULT GUINEA-PIG AND RAT VENTRICULAR MYOCYTES TO OMEGA-3 POLYUNSATURATED FATTY-ACIDS
Autore:
MACLEOD JC; MACKNIGHT ADC; RODRIGO GC;
Indirizzi:
UNIV OTAGO,OTAGO MED SCH,DEPT PHYSIOL DUNEDIN NEW ZEALAND UNIV OTAGO,OTAGO MED SCH,DEPT PHYSIOL DUNEDIN NEW ZEALAND
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 356, anno: 1998,
pagine: 261 - 270
SICI:
0014-2999(1998)356:2-3<261:TEAMRO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT OUTWARD CURRENT; HEART-CELLS; CARDIAC MYOCYTES; PHASE-2 REENTRY; NA+ CHANNELS; FISH OIL; CALCIUM; ARRHYTHMIAS; FIBRILLATION; EPICARDIUM;
Keywords:
EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; ACTION POTENTIAL; CA2+ CURRENT; TRANSIENT OUTWARD CURRENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Macleod et al., "THE ELECTRICAL AND MECHANICAL RESPONSE OF ADULT GUINEA-PIG AND RAT VENTRICULAR MYOCYTES TO OMEGA-3 POLYUNSATURATED FATTY-ACIDS", European journal of pharmacology, 356(2-3), 1998, pp. 261-270

Abstract

Single adult guinea-pig and rat ventricular cardiac myocytes were used to study the effects of two members of the omega 3 class of polyunsaturated fatty acids, docosahexaenoic acid and eicosapentaenoic acid, on the electrical and mechanical activity of cardiac muscle. Docosahexaenoic acid and eicosapentaenoic acid reduced the electrical excitability of both guinea-pig and rat cells in a dose-dependent manner. Both agents produced a dose-dependent negative inotropic response in guinea-pig cells but in the rat cells there was first a dose-dependent positive inotropic effect at low concentrations (< 10 mu M) followed by a negative inotropic effect at higher concentrations (>10 mu M). Possible mechanisms by which these agents affect contraction were studied usingconventional electrophysiological techniques. The polyunsaturated fatty acids reduced the action potential duration and the plateau potential of the guinea-pig cells in a simple, dose-dependent manner. In contrast, the effect on the rat action potential mirrored the inotropic effect. At low concentrations (< 10 mu M) there was a concentration-dependent increase in action potential duration followed by a concentration-dependent decrease at higher concentrations (> 10 mu M). Both polyunsaturated fatty acids decreased the fast Nai current and the L-type Ca2+ current in a concentration-dependent but not use-dependent manner in cells from both species. In the rat cells these agents inhibited thetransient outward current resulting in an increase in the duration ofthe rat action potential. The effects of polyunsaturated fatty acids on the Ca2+ Na+ and K+ currents underlie these changes in the action potentials in guinea-pig and rat heart cells. The effects on the L-typeCa2+ current and action potential duration can also explain both the simple negative inotropic effects of the agents on the guinea-pig cells and the more complex effects on the rat cells. These effects of polyunsaturated fatty acids on membrane currents may account for their anti-arrhythmic properties. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:51:37