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Titolo:
THE DISTRIBUTION OF RADIOLABELED CORTICOTROPIN-RELEASING FACTOR IN PREGNANT RATS - AN INVESTIGATION OF PLACENTAL-TRANSFER TO THE FETUSES
Autore:
WILLIAMS MT; DAVIS HN; MCCREA AE; HENNESSY MB;
Indirizzi:
WRIGHT STATE UNIV,DEPT PSYCHOL,335 FAWCETT HALL,3640 COL GLENN HWY DAYTON OH 45435 WRIGHT STATE UNIV,DEPT PSYCHOL DAYTON OH 45435 SINCLAIR COMMUNITY COLL DAYTON OH 45402
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 3-4, volume: 16, anno: 1998,
pagine: 229 - 234
SICI:
0736-5748(1998)16:3-4<229:TDORCF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOLIC-CLEARANCE RATE; PRENATAL STRESS; BEHAVIOR; HORMONE; PLASMA; ACTH; PHARMACOLOGY; PHYSIOLOGY; RECEPTOR; PASSAGE;
Keywords:
CORTICOTROPIN-RELEASING FACTOR; BLOOD-BRAIN BARRIER; PRENATAL STRESS; PLACENTAL TRANSFER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Williams et al., "THE DISTRIBUTION OF RADIOLABELED CORTICOTROPIN-RELEASING FACTOR IN PREGNANT RATS - AN INVESTIGATION OF PLACENTAL-TRANSFER TO THE FETUSES", International journal of developmental neuroscience, 16(3-4), 1998, pp. 229-234

Abstract

Stress during gestation can have serious consequences on the development of the fetus. Many of these effects appear to be mediated by hormones of the hypothalamic-pituitary-adrenal (HPA) axis. Corticotropin-releasing factor (CRF), released by the hypothalamus during times of stress serves to activate release of pituitary hormones and is also present in law levels in rat plasma. Moreover, the uterus contains significant quantities of CRF at implantation sites, probably from local sources. Therefore, the possibility exists that CRF may cross the placenta and activate the fetal HPA axis. However, the ability of CRF to cross the placenta has not been demonstrated. In the present study, pregnantrats were administered radiolabeled CRF intraperitoneally, and the distribution of the labeled product was determined in the Fetuses and various maternal organs. High levels of activity were observed in the pregnant female's uterus, adrenals, heart and the placentae, but only background levels of activity were detected in the maternal brain. Very low levels of activity were observed in the fetuses, indicating that the transfer of CRF across the placenta is greatly restricted. These findings suggest that maternal CRF has little or no direct effect on thedeveloping fetus during gestational stress. (C) 1998 ISDN. Published by Elsevier Science Ltd.

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Documento generato il 31/03/20 alle ore 19:33:44