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Titolo:
PRENATAL EXPERIENCE AND POSTNATAL STRESS MODULATE THE ADULT NEUROSTEROID AND CATECHOLAMINERGIC STRESS RESPONSES
Autore:
ZIMMERBERG B; BROWN RC;
Indirizzi:
WILLIAMS COLL,BRONFMAN SCI CTR,DEPT PSYCHOL WILLIAMSTOWN MA 01267 WILLIAMS COLL,BRONFMAN SCI CTR,PROGRAM NEUROSCI WILLIAMSTOWN MA 01267
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 3-4, volume: 16, anno: 1998,
pagine: 217 - 228
SICI:
0736-5748(1998)16:3-4<217:PEAPSM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROACTIVE STEROID ALLOPREGNANOLONE; PITUITARY-ADRENAL RESPONSES; GABA-A RECEPTORS; ULTRASONIC VOCALIZATIONS; ALCOHOL EXPOSURE; ETHANOL EXPOSURE; ACTIVE STEROIDS; SEX-DIFFERENCES; RAT; SEPARATION;
Keywords:
ALLOPREGNANOLONE; NEUROACTIVE STEROID; FETAL ALCOHOL SYNDROME; DOPAMINE; SEX DIFFERENCES; MATERNAL SEPARATION; PRENATAL STRESS; ALCOHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
B. Zimmerberg e R.C. Brown, "PRENATAL EXPERIENCE AND POSTNATAL STRESS MODULATE THE ADULT NEUROSTEROID AND CATECHOLAMINERGIC STRESS RESPONSES", International journal of developmental neuroscience, 16(3-4), 1998, pp. 217-228

Abstract

Allopregnanolone (3 alpha-hydroxy-5 alpha-regnan-20-one) is a neuroactive steroid recently shown to be involved in the neurochemical stressresponse via its positive modulation of the GABA, receptor complex. This experiment investigated the effects of postnatal stress (daily maternal separation during the first week of life) on the subsequent adult response to a stressor (10 min forced swim) in Long-Evens rats from one of three prenatal treatment groups (alcohol, pair-fed and control). Indices of stress response were allopregnanolone concentrations in plasma, cortex and hippocampus, and dopamine and norepinephrine concentrations in prefrontal cortex; nucleus accumbens and striatum. Females had higher levels of allopregnanolone than males in both plasma and brain. Prenatal alcohol exposure combined with early maternal separationstress resulted in an increase in the endogenous levels of allopregnanolone in the prefrontal cortex and hippocampus of adult offspring in response to a stressor compared to subjects without a prior history ofpostnatal stress; this effect was greater in females. This increased allopregnanolone was also associated with decreased dopamine and norepinephrine levels in the prefrontal cortex. In the prenatal alcohol-exposed offspring, postnatal maternal separation blunted the increase in dopamine levels in the striatum seen in both control groups. Postnatalmaternal separation increased norepinephrine levels in the nucleus accumbens regardless of prenatal experience, while in the prefrontal cortex only prenatal diet condition (pair-feeding and alcohol) resulted in lower norepinephrine revels. The results of this experiment suggest that experience, both pre- and postnatal, can have long-term consequences for the developing neurochemical responses to stressors. (C) 1998 ISDN. Published by Elsevier Science Ltd.

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Documento generato il 19/01/20 alle ore 06:15:51