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Titolo:
CROCIN AND CROCETIN DERIVATIVES INHIBIT SKIN TUMOR PROMOTION IN MICE
Autore:
KONOSHIMA T; TAKASAKI M; TOKUDA H; MORIMOTO S; TANAKA H; KAWATA E; XUAN LJ; SAITO H; SUGIURA M; MOLNAR J; SHOYAMA Y;
Indirizzi:
KYUSHU UNIV,FAC PHARMACEUT SCI,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812 JAPAN KYUSHU UNIV,FAC PHARMACEUT SCI,HIGASHI KU FUKUOKA 812 JAPAN KYOTO PHARMACEUT UNIV,YAMASHINA KU KYOTO 607 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIGYO KU KYOTO 602 JAPAN UNIV TOKYO,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,BUNKYO KU TOKYO 113JAPAN ALBERT SZENT GYORGYI MED UNIV,DEPT MICROBIOL H-6720 SZEGED HUNGARY
Titolo Testata:
PTR. Phytotherapy research
fascicolo: 6, volume: 12, anno: 1998,
pagine: 400 - 404
SICI:
0951-418X(1998)12:6<400:CACDIS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ETHANOL-INDUCED IMPAIRMENT; MOUSE PULMONARY TUMORS; BARR VIRUS-ACTIVATION; SATIVUS L; 2-STAGE CARCINOGENESIS; IN-VIVO;
Keywords:
CROCUS SATIVUS; CROCIN; EBV-EA INDUCTION; 2-STAGE CARCINOGENESIS; MOUSE SKIN PAPILLOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Konoshima et al., "CROCIN AND CROCETIN DERIVATIVES INHIBIT SKIN TUMOR PROMOTION IN MICE", PTR. Phytotherapy research, 12(6), 1998, pp. 400-404

Abstract

The addition of 100 mu g/mL of a 50% EtOH extract of Crocus sativus (ECS) exhibited significant inhibitory effects on EBV-EA activation andpreserved the high viability of Raji cells. The attenuating effect ofECS was dose-dependent. The oral administration of ECS demonstrated an inhibitory effect on two-stage carcinogenesis of mouse skin papillomas, using DMBA as an initiator and TPA as a promoter. Crocetin gentiobiose glucose ester and crocetin di-glucose ester were less potent thancrocin in inhibiting the EBV-EA induction effect. When crocin was applied before each TPA treatment, it delayed the formation of papillomas; only about 10% of mice bore papillomas at 9 weeks of promotion and after 13 weeks of promotion 20% of mice still bore no papilloma, The effect of crocin was not mimicked by gentiobiose or glucose alone. (C), 1998 John Wiley SL Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:18:54