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Titolo:
ETIOLOGY OF SEVERE IRON OVERLOAD IN A FAMILY WITH HEREDITARY HEMOLYTIC-ANEMIA
Autore:
DYKES A; GURTLER V; FIRKIN F;
Indirizzi:
ST VINCENTS HOSP,DEPT MED FITZROY VIC 3065 AUSTRALIA ST VINCENTS HOSP,DEPT MED FITZROY VIC 3065 AUSTRALIA ST VINCENTS HOSP,DEPT CLIN HAEMATOL FITZROY VIC 3065 AUSTRALIA ST VINCENTS HOSP,DEPT HAEMATOL FITZROY VIC 3065 AUSTRALIA AUSTIN & REPATRIAT MED CTR,DEPT MICROBIOL HEIDELBERG VIC AUSTRALIA
Titolo Testata:
British Journal of Haematology
fascicolo: 5, volume: 102, anno: 1998,
pagine: 1179 - 1181
SICI:
0007-1048(1998)102:5<1179:EOSIOI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA-LINKED HEMOCHROMATOSIS; SIDEROBLASTIC ANEMIAS; SPHEROCYTOSIS; ASSOCIATION;
Keywords:
IRON OVERLOAD; HEMOLYTIC ANEMIA; ERYTHROID HYPERPLASIA; C282Y MUTATION; HEMOCHROMATOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
A. Dykes et al., "ETIOLOGY OF SEVERE IRON OVERLOAD IN A FAMILY WITH HEREDITARY HEMOLYTIC-ANEMIA", British Journal of Haematology, 102(5), 1998, pp. 1179-1181

Abstract

Severe iron overload is a reported complication of certain erythroid disorders which are characterized by increased erythropoietic activity, Proposed mechanisms include enhancement of iron absorption secondaryto increased erythroid activity and coexistent heterozygosity or homozygosity for haemochromatosis. We performed PCR-based analysis for thehaemochromatosis-related HFE C282Y mutation in an extended family with inherited haemolytic anaemia in which several members exhibited ironoverload. The results demonstrated iron overload was associated with homozygosity but not heterozygosity for this mutation. Such an association may also exist in other erythroid disorders in which iron overload has been reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 17:46:28