Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PHARMACOLOGICAL STUDIES ON THE NOVEL ANTIALLERGIC DRUG HQL-79 - II - ELUCIDATION OF MECHANISMS FOR ANTIALLERGIC AND ANTIASTHMATIC EFFECTS
Autore:
MATSUSHITA N; ARITAKE K; TAKADA A; HIZUE M; HAYASHI K; MITSUI K; HAYASHI M; HIROTSU I; KIMURA Y; TANI T; NAKAJIMA H;
Indirizzi:
ROHTO PHARMACEUT CO,PHARMACOL RES GRP,BIOCLIN RES DIV,IKUNO KU,1-8-1 TATSUMI NISHI OSAKA 5448666 JAPAN SUMITOMO MET IND LTD,DIV BIOMED,HIGH QUAL LIFE RES LABS,NEW DRUG RES DEPT KYOTO 6190237 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 1, volume: 78, anno: 1998,
pagine: 11 - 22
SICI:
0021-5198(1998)78:1<11:PSOTNA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIGS; MAST-CELLS; AIRWAY HYPERRESPONSIVENESS; HYPERSENSITIVITY REACTIONS; HISTAMINE-RELEASE; IMMEDIATE; OXATOMIDE; ASTHMA; PROSTAGLANDIN-D2; INFLAMMATION;
Keywords:
ANTIHISTAMINE; PROSTAGLANDIN D-2; PROSTAGLANDIN E-2; PROSTAGLANDIN D SYNTHASE; HQL-79;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
N. Matsushita et al., "PHARMACOLOGICAL STUDIES ON THE NOVEL ANTIALLERGIC DRUG HQL-79 - II - ELUCIDATION OF MECHANISMS FOR ANTIALLERGIC AND ANTIASTHMATIC EFFECTS", Japanese Journal of Pharmacology, 78(1), 1998, pp. 11-22

Abstract

The effects of ydryloxy-1-{3-(1H-tetrazol-5-yl)-propyl}piperidine (HQL-79), a newly developed antiallergic drug, on various chemical mediators and on chemical mediator release were investigated. Orally administered HQL-79 strongly inhibited the histamine-induced skin reaction inrats, and histamine- and 5-hydroxytryptamine (5-HT)-induced bronchoconstriction in guinea pigs. HQL-79 inhibited antigen-induced release ofleukotriene (LT) B-4, LTC4, histamine and prostaglandin (PG)D-2 from the chopped lung tissues of actively sensitized guinea pigs. On the other hand, release of PGE(2), one of the bronchoprotective prostanoids,was significantly enhanced by HQL-79. In an in vivo experiment, chronic administration of HQL-79 clearly reduced PGD(2) contents and enhanced PGE(2) contents in the lungs of repeatedly antigen-exposed guinea pigs. In biochemical studies, HQL-79 inhibited mouse spleen PGD synthase in a concentration-dependent manner. None of the antiallergics such as epinastine, terfenadine, oxatomide and cetirizine inhibited the PGDsynthase. HQL-79 did not affect PGE synthase in sheep vesicular glandmicrosomes. These results suggest that antiallergic and antiasthmaticeffects of HQL-79 could be ascribed to antihistaminic- and anti-5-MT effects, chemical mediator release inhibition, PGE(2)-release enhancement and PGD synthase inhibition. It is considered, in particular, thatthe differential modulation of PGD(2) and PGE(2) production is a conspicuous pharmacological feature of HQL-79.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:48:19