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Titolo:
COMPARISON OF METOPROLOL AND SOTALOL IN PREVENTING VENTRICULAR TACHYARRHYTHMIAS AFTER THE IMPLANTATION OF A CARDIOVERTER DEFIBRILLATOR/
Autore:
SEIDL K; HAUER B; SCHWICK NG; ZAHN R; SENGES J;
Indirizzi:
HERZZENTRUM LUDWIGSHAFEN,DEPT CARDIOL,BREMSERSTR 79 D-67063 LUDWIGSHAFEN GERMANY
Titolo Testata:
The American journal of cardiology
fascicolo: 6, volume: 82, anno: 1998,
pagine: 744 - 748
SICI:
0002-9149(1998)82:6<744:COMASI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ANTIARRHYTHMIC-DRUG EFFICACY; CARDIOVERTER-DEFIBRILLATOR; TACHYCARDIA; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K. Seidl et al., "COMPARISON OF METOPROLOL AND SOTALOL IN PREVENTING VENTRICULAR TACHYARRHYTHMIAS AFTER THE IMPLANTATION OF A CARDIOVERTER DEFIBRILLATOR/", The American journal of cardiology, 82(6), 1998, pp. 744-748

Abstract

The purpose of this prospective study was to evaluate, on an intention-to-treat basis, the efficacy of d,l-sotalal and metoprolol with regards to the recurrence of arrhythmic events after implantable cardioverter defibrillator (ICD) implantation. After ICD implantation, 70 patients were randomly assigned to treatment with either metoprolol (mean dosage 104 +/- 37 mg/day in 35 patients) or d,l-sotalol (mean dosage 242 +/- 109 mg/day in 35 patients). During follow up ventricular tachycardia (VT), fast VT, and ventricular fibrillation (VF) episodes were calculated. Metoprolol treatment led to a marked reduction in the recurrence of arrhythmic events. Actuarial rates for absence of VT recurrence at 1 and 2 years were significantly higher in the metoprolol group compared with the d,l-sotalol group (83% and 80% vs 57% and 51%, respectively, p = 0.016). The actuarial rates for absence of fast VT or VF were 80% in the metoprolol group compared with 46% in the d,l-sotalol group (p = 0.002). During a follow up of 26 +/- 16 months, there were 3deaths in the metoprolol group compared with 6 deaths in the d,l-sotalol group. Actuarial rates of overall survival were not significantly different in the 2 groups (91% vs 83%, p = 0.287). In this prospective, randomized, controlled study the recurrence rate of ventricular tachyarrhythmias in patients treated with metoprolol was lower than in patients treated by d,l-sotalol. (C) 1998 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:32:22