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Titolo:
IMPACT OF PREEXISTING AND INDUCED HUMORAL AND CELLULAR IMMUNE-RESPONSES IN AN ADENOVIRUS-BASED GENE-THERAPY PHASE-I CLINICAL-TRIAL FOR LOCALIZED MESOTHELIOMA
Autore:
MOLNARKIMBER KL; STERMAN DH; CHANG M; KANG EH; ELBASH M; LANUTI M; ELSHAMI A; GELFAND K; WILSON JM; KAISER LR; ALBELDA SM;
Indirizzi:
UNIV PENN,MED CTR,HARRISON DEPT SURG RES,DEPT SURG,THORAC SURG SECT,351 STEMMLER HALL PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MED,DIV MED,PULM CRIT CARE DIV PHILADELPHIA PA19104 UNIV PENN,MED CTR,DEPT MOL & CELLULAR ENGN PHILADELPHIA PA 19104 UNIV PENN,MED CTR,INST HUMAN GENE THERAPY PHILADELPHIA PA 19104
Titolo Testata:
Human gene therapy
fascicolo: 14, volume: 9, anno: 1998,
pagine: 2121 - 2133
SICI:
1043-0342(1998)9:14<2121:IOPAIH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS THYMIDINE KINASE; LARGE-T-ANTIGEN; RECOMBINANT ADENOVIRUS; CYSTIC-FIBROSIS; NASAL EPITHELIUM; AIRWAY EPITHELIA; COLON-CARCINOMA; GAP-JUNCTIONS; LUNG-CANCER; COTTON RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
K.L. Molnarkimber et al., "IMPACT OF PREEXISTING AND INDUCED HUMORAL AND CELLULAR IMMUNE-RESPONSES IN AN ADENOVIRUS-BASED GENE-THERAPY PHASE-I CLINICAL-TRIAL FOR LOCALIZED MESOTHELIOMA", Human gene therapy, 9(14), 1998, pp. 2121-2133

Abstract

Little is known about the immune responses induced by recombinant adenoviral (Ad) vectors in humans, The humoral and cellular immune responses were therefore analyzed in 21 patients with localized malignancy (mesothelioma), who received intrapleurally high doses of a replication-defective Ad5 vector carrying a suicide gene, Eight of 21 patients had pretreatment titers of neutralizing antibodies (NAb) to Ad at greater than or equal to 1:100. Peripheral blood mononuclear cells (PBMCs) proliferated in response to adenoviral 5 structural proteins before treatment in 17 of 21 patients, Preexisting humoral and cellular immunitydid not preclude gene transfer, Vector instillation induced high titers of nonneutralizing and neutralizing anti-Ad antibody (4- to 341-fold increase in 18 of 20 patients) in a dose-dependent manner, Three patients generated antibodies to the transgene, herpes simplex virus thymidine kinase, Ad5-specific proliferation of PBMCs increased significantly (>3-fold) after vector administration in 12 of 21 patients in a dose-dependent manner, Thus, replication-defective Ad5 administered intrapleurally induced significant humoral and cellular immune responses that induced no obvious adverse clinical sequelae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:48:50