Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FEASIBILITY OF IMAGING PHOTODYNAMIC INJURY TO TUMORS BY HIGH-RESOLUTION POSITRON-EMISSION-TOMOGRAPHY
Autore:
MOORE JV; WALLER ML; ZHAO S; DODD NJF; ACTON PD; JEAVONS AP; HASTINGS DL;
Indirizzi:
CHRISTIE HOSP NHS TRUST,PATERSON INST CANC RES MANCHESTER M20 4BX LANCS ENGLAND UNIV COLL LONDON,INST NUCL MED LONDON ENGLAND
Titolo Testata:
European journal of nuclear medicine
fascicolo: 9, volume: 25, anno: 1998,
pagine: 1248 - 1254
SICI:
0340-6997(1998)25:9<1248:FOIPIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; THERAPY; INVIVO; FLUORODEOXYGLUCOSE; SPECTROSCOPY; TUMORS;
Keywords:
PHOTODYNAMIC THERAPY; POSITRON EMISSION TOMOGRAPHY FLUORODEOXYGLUCOSE; MAGNETIC RESONANCE; MAMMARY CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.V. Moore et al., "FEASIBILITY OF IMAGING PHOTODYNAMIC INJURY TO TUMORS BY HIGH-RESOLUTION POSITRON-EMISSION-TOMOGRAPHY", European journal of nuclear medicine, 25(9), 1998, pp. 1248-1254

Abstract

One early effect of the treatment of tumours by the new modality photodynamic therapy (PDT) is a reduction in tumour glucose levels. We have employed the widely used positron-emitting glucose analogue flurorine-18 fluoro-2-deoxy-D-glucose ([F-18]-FDG), to determine whether, in principle, PDT-induced injury might be delineated non-invasively and quantitatively by positron emission tomography (PET). The scanner was ofthe high-density avalanche-chamber (HIDAC) type with a resolution of 2.6 mm. Subcutaneous T50/80 mouse mammary rumours, sensitised by haematoporphyrin ester, were illuminated by graded doses of interstitial 630 nm light. Thirty hours later, any remaining viable tumour was detected (a) by region-of-interest analysis of the PET images and (b) by gamma counting the excised tumour. PET measurements of % uptake of [F-18]-FDG into tumour correlated closely with ex vivo gamma counting (slope=0.976, r(2)=0.995), validating the in situ method. Uptake into untreated, control tumours was 3.8%+/-1.1% of the injected activity. Uptake of [F-18]-FDG into treated rumours decreased by 0.7% for every 100 mm(3) reduction in remaining viable histological volume. Outcome was further compared with that measured by (a) T2-weighted proton imaging on a4.7-T magnetic resonance imaging (MRT) system and (b) histological analysis of subsequently sectioned tumours. PET using [F-18]-FDG described the absolute volume of surviving tumour histological mass to the same degree as high-resolution MRI. The conclusion of these initial studies is that PET with [F-18]-FDG, although non-specific, quantitativelydescribed at early times the extent of tumour destruction by PDT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:01:23