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Titolo:
BIOMARKERS IN BARRETTS-ESOPHAGUS (REVIEW)
Autore:
VANLIESHOUT EMM; JANSEN JBMJ; PETERS WHM;
Indirizzi:
UNIV NIJMEGEN ST RADBOUD HOSP,DEPT GASTROENTEROL,POB 9101 NL-6500 HB NIJMEGEN NETHERLANDS UNIV NIJMEGEN ST RADBOUD HOSP,DEPT GASTROENTEROL NL-6500 HB NIJMEGEN NETHERLANDS
Titolo Testata:
International journal of oncology
fascicolo: 4, volume: 13, anno: 1998,
pagine: 855 - 864
SICI:
1019-6439(1998)13:4<855:BIB(>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; COLUMNAR-LINED ESOPHAGUS; HIGH-GRADE DYSPLASIA; ORNITHINE DECARBOXYLASE ACTIVITY; FLOW CYTOMETRIC ABNORMALITIES; POLYMERASE CHAIN-REACTION; P53 PROTEIN ACCUMULATION; TUMOR-SUPPRESSOR GENES; CELL NUCLEAR ANTIGEN; BLOOD-GROUP ANTIGENS;
Keywords:
ALLELIC LOSS; BARRETTS EPITHELIUM; BARRETTS ADENOCARCINOMA; BIOMARKER; BIOTRANSFORMATION; ESOPHAGUS; FLOW CYTOMETRY; MALIGNANT TRANSFORMATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
167
Recensione:
Indirizzi per estratti:
Citazione:
E.M.M. Vanlieshout et al., "BIOMARKERS IN BARRETTS-ESOPHAGUS (REVIEW)", International journal of oncology, 13(4), 1998, pp. 855-864

Abstract

Patients with Barrett's esophagus where squamous esophageal epithelium has been replaced by columnar epithelium containing goblet cells have an increased risk of esophageal adenocarcinoma. Unfortunately, most of those adenocarcinomas are detected at an advanced stage in which they are incurable. Many biomarkers have been studied, trying to identify the subset of patients who are at very high risk for adenocarcinoma. Dysplasia is at present the 'golden standard' for the risk of adenocarcinoma. However, over-expression of p53. allelic losses, proliferation indices, flow cytometric abnormalities, accumulation of acidic fibroblast growth factor, expression of blood group antigens and sucrase-isomaltase during the Barrett's to adenocarcinoma sequence appear promising. However. additional information is needed to justify routine application in clinical practice and in define their role in surveillance programs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 15:40:38