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Titolo:
LOSS OF HETEROZYGOSITY OF BRCA1, BRCA2 AND ATM GENES IN SPORADIC INVASIVE DUCTAL BREAST-CARCINOMA
Autore:
RIO PG; PERNIN D; BAY JO; ALBUISSON E; KWIATKOWSKI F; DELATOUR M; BERNARDGALLON DJ; BIGNON YJ;
Indirizzi:
CTR JEAN PERRIN,MOL ONCOL LAB,INSERM,CRI 9502,EA 2145,BP 392 F-63011 CLERMONT FERRA FRANCE CTR JEAN PERRIN,MOL ONCOL LAB,INSERM,CRI 9502,EA 2145 F-63011 CLERMONT FERRA FRANCE CTR JEAN PERRIN,SERV ANATOMOPATHOL F-63011 CLERMONT FERRA FRANCE INSERM,U484 F-63005 CLERMONT FERRA FRANCE UNIV AUVERGNE,SERV BIOSTAT CLERMONT FERRA FRANCE
Titolo Testata:
International journal of oncology
fascicolo: 4, volume: 13, anno: 1998,
pagine: 849 - 853
SICI:
1019-6439(1998)13:4<849:LOHOBB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATAXIA-TELANGIECTASIA; CHROMOSOME 13Q12-Q13; OVARIAN-CANCER; MUTATIONS; REGION; SUSCEPTIBILITY; TUMORS; IDENTIFICATION; 11Q23.3; 13Q;
Keywords:
SPORADIC BREAST CANCER; LOSS OF HETEROZYGOSITY; BRCA1; BRCA2; ATM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Rio et al., "LOSS OF HETEROZYGOSITY OF BRCA1, BRCA2 AND ATM GENES IN SPORADIC INVASIVE DUCTAL BREAST-CARCINOMA", International journal of oncology, 13(4), 1998, pp. 849-853

Abstract

The present study was undertaken to analyse the loss: of heterozygosity (LOH) of the three genes, BRCA1, BRCA2 and ATM, and their correlation to clinicopathological parameters in sporadic breast cancer. We studied 59 sets of invasive ductal carcinoma, compared to matched normal control DNA. Microsatellite markers intragenic to BRCA1 (D17S1323, D17S1322, D17S855), BRCA2 (D13S1699. D13S1701, D13S1695) and ATM (D11S2179) were simultaneously used, in addition. I,ne marker telomeric to BRCA2 (D13S1694) and four markers flanking ATM were analysed (D11S1816, D11S1819. D11S1294, D11S1818). Thirty-one per cent of the informative cases showed loss of heterozygosity for the BRCA1 gene, 22.8% for BRCA2? gene and 40% for ATM. LOH of BRCA1 correlated with high grade tumors(p=0.0005) and negative hormone receptors (p=0.01). LOH of ATM correlated with higher grade (p=0.03) and a younger age at diagnosis (p=0.03) in our set of tumors. No correlations were detected between BRCA2 LOH and any of the analysed clinicopathological parameters. However. a correlation was detected between allelic loss of the D13S1694 marker, telomeric to BRCA2, and larger tumor sizes: and negative estrogen receptors, favoring the hypothesis of the presence of another putative tumor suppressor gene, telomeric to BRCA2. in the 13q12-q14 region. Only 11 tumors had LOH at more than one of the three genes, most of them (6/11) associated LOH of BRCA1 and ATM. One tumor only combined loss of the three genes BRCA1, BRCA2 and ATM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:09:52