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Titolo:
MECHANISMS OF SEVERE, IMMEDIATE REACTIONS TO IODINATED CONTRAST MATERIAL
Autore:
LAROCHE D; AIMONEGASTIN I; DUBOIS F; HUET H; GERARD P; VERGNAUD MC; MOUTONFAIVRE C; GUEANT JL; LAXENAIRE MC; BRICARD H;
Indirizzi:
CTR HOSP REG UNIV,LAB MED PHYS,AVE COTE NACRE F-14033 CAEN FRANCE CTR HOSP REG UNIV,DEPT ANESTHESIOL F-14033 CAEN FRANCE CTR HOSP REG UNIV,DEPT RADIOL F-14033 CAEN FRANCE CTR HOSP REG UNIV,DEPT PNEUMOL F-14033 CAEN FRANCE HOP BRABOIS,LAB PROT BIOCHEM VANDOEUVRE NANCY FRANCE CTR HOSP REG UNIV,DEPT ANESTHESIOL NANCY FRANCE
Titolo Testata:
Radiology
fascicolo: 1, volume: 209, anno: 1998,
pagine: 183 - 190
SICI:
0033-8419(1998)209:1<183:MOSIRT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELL TRYPTASE; ANAPHYLACTOID REACTIONS; ADVERSE REACTIONS; PLASMA HISTAMINE; RADIOCONTRAST MATERIAL; MONOCLONAL-ANTIBODIES; STING CHALLENGE; MEDIA; COMPLEMENT; ACTIVATION;
Keywords:
ANAPHYLAXIS AND ALLERGY; CONTRAST MEDIA, COMPARATIVE STUDIES; CONTRAST MEDIA, COMPLICATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D. Laroche et al., "MECHANISMS OF SEVERE, IMMEDIATE REACTIONS TO IODINATED CONTRAST MATERIAL", Radiology, 209(1), 1998, pp. 183-190

Abstract

PURPOSE: To measure and elucidate the mechanisms of presumed mediators of unexpected severe, immediate reactions to iodinated contrast materials. MATERIALS AND METHODS: In a multicenter study, 20 patients withmild to severe reactions to iodinated contrast material and 20 control subjects without reactions were evaluated. Ionic contrast material was associated with 18 (90%) of 20 reactions. Concentrations of plasma histamine, tryptase, urinary methylhistamine, specific immunoglobulin E (IgE) against ioxitalamate or ioxaglate, and the anaphylatoxins C3a and C4a were measured with radioimmunoassays; complement C3 and C4 levels were measured with nephelometry. RESULTS: Histamine levels were increased in 14 patients; tryptase levels, in 16; and methylhistamine levels, in six. Histamine and tryptase values correlated with the severity of the reaction (P < .02 and P < .004, respectively). Significantlyhigher levels of specific IgE against ioxaglate (P < .005) and ioxitalamate (P = .045) were found in patients. No differences were found for complement fractions. Skin test results in two patients with life-threatening reactions were positive for the administered contrast material. CONCLUSION: Histamine release and mast cell triggering are relatedto severe reactions. An IgE-related mechanism is strongly suspected. Radiologists should be trained to identify and treat anaphylactic shock in patients who react to iodinated contrast material.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:07:10