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Titolo:
OSCILLATORY POTENTIALS IN THE RETINA - WHAT DO THEY REVEAL
Autore:
WACHTMEISTER L;
Indirizzi:
UMEA UNIV,DEPT OPHTHALMOL S-90185 UMEA SWEDEN
Titolo Testata:
Progress in retinal and eye research
fascicolo: 4, volume: 17, anno: 1998,
pagine: 485 - 521
SICI:
1350-9462(1998)17:4<485:OPITR->2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATIONARY NIGHT BLINDNESS; SCOTOPIC THRESHOLD RESPONSE; SOURCE DENSITY ANALYSIS; DEVELOPING RAT RETINA; DIABETIC-RETINOPATHY; POSTNATAL-DEVELOPMENT; LIGHT-ADAPTATION; DARK-ADAPTATION; B-WAVE; MUDPUPPY RETINA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
226
Recensione:
Indirizzi per estratti:
Citazione:
L. Wachtmeister, "OSCILLATORY POTENTIALS IN THE RETINA - WHAT DO THEY REVEAL", Progress in retinal and eye research, 17(4), 1998, pp. 485-521

Abstract

This chapter is an overview of current knowledge on the oscillatory potentials (OPs) of the retina. The first section describes the characteristics of the OPs. The basic, adaptational, pharmacological and developmental characteristics of the OPs are different from the a- and b-waves: the major components of the electroretinogram (ERG). The OPs aremost easily recorded in mesopic adaptational conditions and reflect rapid changes of adaptation. They represent photopic and scotopic processes, probably an interaction between cone and rod activity in the retina. The OPs are sensitive to disruption of inhibitory (dopamine, GABA-, and glycine-mediated) neuronal pathways and are not selectively affected by excitatory amino acids. The earlier OPs are associated with the on-components and the late OPs with the off-components in response to a brief stimulus of light. The postnatal appearance of the first oscillatory activity is preceded by the a- and b-waves. The earlier OPs appear postnatally prior to, and mature differently from, the later ones. The second section deals with present views on the origin of the OPs. These views are developed from experimental OPs reflect neuronal synaptic activity in inhibitory feedback pathways initiated by the amacrines in the inner retina. The bipolar (or the interplexiform) cells are the probable generators of the OPs. Dopaminergic neurons, probably amacrines (or interplexiform cells), are involved in the generation ofthe OPs. The earlier OPs are generated in neurons related to the on-pathway of the retina and the later ones to the off-channel system. Peptidergic neurons may be indirectly involved as modulators. The individual OPs seem to represent the activation of several retinal generators. The earlier OPs are more dependent on an intact rod function and thelater ones on an intact cone system. Thus, the OPs are good indicators of neuronal adaptive mechanisms in the retina and are probably the only post-synaptic neuronal components that can be recorded in the ERG except when structured stimuli are used. The last section describes the usefulness of the oscillatory response as an instrument to study thepostnatal development of neuronal adaptation of the retina. In this section clinical examples of the sensitivity of the OPs for revealing early disturbance in neuronal function in different retinal diseases such as pediatric, vascular and degenerative retinopathies are also given. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 01:16:11